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Cat. No.: HY-N21563

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4'-Phosphopantothenoylcysteine

Name: 4'-Phosphopantothenoylcysteine
Brand: MedChemExpress
SKU: HY-N21563
Availability: PreOrder

(Synonyms: Pantothenoylcysteine 4'-phosphate; PPC)

4'-Phosphopantothenoylcysteine (Pantothenoylcysteine 4'-phosphate) serves as a substrate for phosphopantothenoylcysteine decarboxylase (PPC-DC) and MdHAL3. 4'-Phosphopantothenoylcysteine enables flavin-mediated decarboxylation of the cysteine moiety via formation of a charge-transfer complex and generation of a thioaldehyde intermediate. 4'-Phosphopantothenoylcysteine is a metabolism-related biomarker and a raw material for coenzyme A synthesis, and it participates in the regulation of the TCA cycle. 4'-Phosphopantothenoylcysteine can be used in studies related to hepatocellular carcinoma.

For research use only. We do not sell to patients.

CAS No.: 7196-09-0
Formula: C₁₂H₂₃N₂O₉PS
Molecular Weight:402.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

4'-Phosphopantothenoylcysteine Chemical Structure

CAS No.: 7196-09-0

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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

4'-Phosphopantothenoylcysteine (Pantothenoylcysteine 4'-phosphate) (0.5 mM; 0.3-5.0 mM) is catalyzed for decarboxylation by human PPC-DC (HsCoaC) with a K_m of 118.5 µM and a kcat of 2.9 s⁻¹, and protects the enzyme from inactivation by PPan∆SH^[1].
4'-Phosphopantothenoylcysteine (5.0 mM; 0-28 h) forms a time-dependent thiolate-flavin to enethiolate-flavin charge-transfer complex with human PPC-DC (HsCoaC), exhibiting an initial absorbance maximum at 580 nm that shifts to 690 nm over hours^[1].
4'-Phosphopantothenoylcysteine (5.0 mM; 0-28 h) induces reduction and slow reoxidation of the flavin cofactor in the C173S mutant of human PPC-DC, regenerating the enethiolate-flavin charge-transfer complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7196-09-0
Molecular Weight 402.36
Formula C₁₂H₂₃N₂O₉PS
SMILES

O=P(O)(O)OCC(C)(C)[C@@H](O)C(NCCC(N[C@@H](CS)C(O)=O)=O)=O
Synonyms

Pantothenoylcysteine 4'-phosphate; PPC
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Strauss E, et al. Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry. 2004 Dec 14;43(49):15520-33. [Content Brief]

[2]. Strauss E, et al. Mechanistic studies on phosphopantothenoylcysteine decarboxylase. J Am Chem Soc. 2001 Jul 4;123(26):6449-50.

[3]. Yang S, et al. MdHAL3, a 4'-phosphopantothenoylcysteine decarboxylase, is involved in the salt tolerance of autotetraploid apple. Plant cell reports. 2020 Nov;39(11):1479-1491.

[4]. Li F, et al. UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin. Journal of pharmaceutical and biomedical analysis. 2016 Jun 05;125:310-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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4'-Phosphopantothenoylcysteine

All Endogenous Metabolite Isoforms