7196-09-0
Chemical Structure
4'-Phosphopantothenoylcysteine
Synonym(s): Pantothenoylcysteine 4'-phosphate; PPC
- CAS No.: 7196-09-0
- Formula:C12H23N2O9PS
- Molecular Weight:402.36
InChIKey: XQYALQVLCNHCFT-CBAPKCEASA-N
SMILES: O=P(O)(O)OCC(C)(C)[C@@H](O)C(NCCC(N[C@@H](CS)C(O)=O)=O)=O
Biological Activity: 4'-Phosphopantothenoylcysteine (Pantothenoylcysteine 4'-phosphate) serves as a substrate for phosphopantothenoylcysteine decarboxylase (PPC-DC) and MdHAL3. 4'-Phosphopantothenoylcysteine enables flavin-mediated decarboxylation of the cysteine moiety via formation of a charge-transfer complex and generation of a thioaldehyde intermediate. 4'-Phosphopantothenoylcysteine is a metabolism-related biomarker and a raw material for coenzyme A synthesis, and it participates in the regulation of the TCA cycle. 4'-Phosphopantothenoylcysteine can be used in studies related to hepatocellular carcinoma[1][2][3][4].
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4'-Phosphopantothenoylcysteine | 4'-Phosphopantothenoylcysteine (Pantothenoylcysteine 4'-phosphate) serves as a substrate for phosphopantothenoylcysteine decarboxylase (PPC-DC) and MdHAL3. 4'-Phosphopantothenoylcysteine enables flavin-mediated decarboxylation of the cysteine moiety via formation of a charge-transfer complex and generation of a thioaldehyde intermediate. 4'-Phosphopantothenoylcysteine is a metabolism-related biomarker and a raw material for coenzyme A synthesis, and it participates in the regulation of the TCA cycle. 4'-Phosphopantothenoylcysteine can be used in studies related to hepatocellular carcinoma. | |||||||||||||||||||||
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References
- [1]. Strauss E, et al. Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry. 2004 Dec 14;43(49):15520-33. [Content Brief]
- [2]. Strauss E, et al. Mechanistic studies on phosphopantothenoylcysteine decarboxylase. J Am Chem Soc. 2001 Jul 4;123(26):6449-50.
- [3]. Yang S, et al. MdHAL3, a 4'-phosphopantothenoylcysteine decarboxylase, is involved in the salt tolerance of autotetraploid apple. Plant cell reports. 2020 Nov;39(11):1479-1491.
- [4]. Li F, et al. UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin. Journal of pharmaceutical and biomedical analysis. 2016 Jun 05;125:310-8.
