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Cat. No.: HY-131954

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5-HT3 antagonist 4

5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice.

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CAS No.: 930478-88-9
Formula: C₁₆H₁₂ClN₃O
Molecular Weight:297.74

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

5-HT3 antagonist 4 Chemical Structure

CAS No.: 930478-88-9

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Biological Activity
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- In Vivo
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Biological Activity

Description

5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice^[1].

All 5-HT Receptor Isoforms :

In Vivo

5-HT3 antagonist 4 (4i) (0.5 and 1mg/kg/day, i.p.; for 4-weeks) ameliorates diabetes-induced depressive-like behavior and serotonin deficits in diabetes mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 930478-88-9
Molecular Weight 297.74
Formula C₁₆H₁₂ClN₃O
SMILES

O=C(C1=NC2=CC=CC=C2N=C1)NC3=CC=CC(Cl)=C3C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deepali Gupta, et al. A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system. Behav Brain Res. 2016 Jan 15;297:41-50. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-HT3 antagonist 4

High-Throughput Bioactive Compound Library

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

5-HT3 antagonist 4 Related Classifications

HY-131954 Related Classifications