5-HT6 agonist 1
5-HT6 agonist 1 (Compound 19) is a 5-HT6 agonist (Ki: 5 nM). 5-HT6 agonist 1 has antidepressant-like properties, and improves cognitive deficits. 5-HT6 agonist 1 also inhibits platelet aggregation. 5-HT6 agonist 1 has high metabolic stability.
For research use only. We do not sell to patients.
- Formula: C17H22Cl2N6S
- Molecular Weight:413.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Ki: 5 nM[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>100 μM
Compound: 19
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Neuroprotective activity against H202 induced oxidative stress in human HepG2 cells measured after 1 hr by DCFH-DA staining based analysis
Neuroprotective activity against H202 induced oxidative stress in human HepG2 cells measured after 1 hr by DCFH-DA staining based analysis
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[PMID: 37567058] |
| SH-SY5Y | IC50 |
>100 μM
Compound: 19
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Neuroprotective activity against H202 induced oxidative stress in human SH-SY5Y cells measured after 1 hr by DCFH-DA staining based analysis
Neuroprotective activity against H202 induced oxidative stress in human SH-SY5Y cells measured after 1 hr by DCFH-DA staining based analysis
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[PMID: 37567058] |
Chemical Information
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Molecular Weight 413.37
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Formula C17H22Cl2N6S
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SMILES
CCC(C1=NC(N)=NC(N2CCN(C)CC2)=N1)SC3=C(Cl)C=CC(Cl)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Czarnota-Łydka K, et al. Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease. Eur J Med Chem. 2023 Nov 5;259:115695. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-HT6 agonist 1 Related Classifications
HY-155116 Related Classifications
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