5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
Based on 1 Customer Validation
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 142808-44-4
- Formula: C46H50F2N5O8P
- Molecular Weight:869.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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DMT-2′Fluoro-dU Phosphoramidite -
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2'-OMe-G(ibu) Phosphoramidite
Biological Activity
Description
Chemical Information
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CAS No. 142808-44-4
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Appearance Solid
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Molecular Weight 869.89
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Formula C46H50F2N5O8P
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Color White to off-white
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SMILES
CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C(F)(F)[C@H](N2C(N=C(NC(C3=CC=CC=C3)=O)C=C2)=O)O[C@@H]1COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (114.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1496 mL | 5.7479 mL | 11.4957 mL | 28.7393 mL |
| 5 mM | 0.2299 mL | 1.1496 mL | 2.2991 mL | 5.7479 mL | |
| 10 mM | 0.1150 mL | 0.5748 mL | 1.1496 mL | 2.8739 mL | |
| 15 mM | 0.0766 mL | 0.3832 mL | 0.7664 mL | 1.9160 mL | |
| 20 mM | 0.0575 mL | 0.2874 mL | 0.5748 mL | 1.4370 mL | |
| 25 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1496 mL | |
| 30 mM | 0.0383 mL | 0.1916 mL | 0.3832 mL | 0.9580 mL | |
| 40 mM | 0.0287 mL | 0.1437 mL | 0.2874 mL | 0.7185 mL | |
| 50 mM | 0.0230 mL | 0.1150 mL | 0.2299 mL | 0.5748 mL | |
| 60 mM | 0.0192 mL | 0.0958 mL | 0.1916 mL | 0.4790 mL | |
| 80 mM | 0.0144 mL | 0.0718 mL | 0.1437 mL | 0.3592 mL | |
| 100 mM | 0.0115 mL | 0.0575 mL | 0.1150 mL | 0.2874 mL |
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite Related Classifications
HY-154222 Related Classifications
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