5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)

Name: 5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
Brand: MedChemExpress
SKU: HY-148505
Rating: 4.5 (0 reviews)

Cat. No.: HY-148505 Purity: 98.99%: Data Sheet
COA

SDS
Handling Instructions
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5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.

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5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite) 화학구조

CAS No. : 1197033-17-2

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite can be combined with other modified nucleotides (such as MOE, DNA) to synthesize chimeric antisense oligonucleotides (ASO)^[1].
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite can be used to synthesize S-cEt-modified antisense oligonucleotides (ASO) D3 targeting mouse PTEN mRNA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

889.97

화학식

C₄₉H₅₆N₅O₉P

CAS No.

1197033-17-2

Appearance

Solid

Color

White to off-white

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C(N=C(C(C)=C2)NC(C3=CC=CC=C3)=O)=O)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 116.67 mg/mL (131.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1236 mL	5.6182 mL	11.2363 mL
5 mM	0.2247 mL	1.1236 mL	2.2473 mL
10 mM	0.1124 mL	0.5618 mL	1.1236 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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Working solution concentration: mg/mL

순도&문서

Purity: 99.17%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (262 KB) HNMR (283 KB) CNMR (340 KB) RP-HPLC (249 KB)

Handling Instructions (2659 KB)

References

[1]. Yu J, et al. Synthesis and antisense properties of 2'-O-(2S-methoxypropyl)-RNA-modified gapmer antisense oligonucleotides. ChemMedChem. 2014 Sep;9(9):2040-4. [Content Brief]

[2]. Seth P P, et al. Synthesis and biophysical evaluation of 2′, 4′-constrained 2′ O-methoxyethyl and 2′, 4′-constrained 2′ O-ethyl nucleic acid analogues. The Journal of organic chemistry, 2010, 75(5): 1569-1581.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1236 mL	5.6182 mL	11.2363 mL	28.0908 mL
	5 mM	0.2247 mL	1.1236 mL	2.2473 mL	5.6182 mL
	10 mM	0.1124 mL	0.5618 mL	1.1236 mL	2.8091 mL
	15 mM	0.0749 mL	0.3745 mL	0.7491 mL	1.8727 mL
	20 mM	0.0562 mL	0.2809 mL	0.5618 mL	1.4045 mL
	25 mM	0.0449 mL	0.2247 mL	0.4495 mL	1.1236 mL
	30 mM	0.0375 mL	0.1873 mL	0.3745 mL	0.9364 mL
	40 mM	0.0281 mL	0.1405 mL	0.2809 mL	0.7023 mL
	50 mM	0.0225 mL	0.1124 mL	0.2247 mL	0.5618 mL
	60 mM	0.0187 mL	0.0936 mL	0.1873 mL	0.4682 mL
	80 mM	0.0140 mL	0.0702 mL	0.1405 mL	0.3511 mL
	100 mM	0.0112 mL	0.0562 mL	0.1124 mL	0.2809 mL