5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
Based on 1 Customer Validation
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.
For research use only. We do not sell to patients.
- Purity : 98.99%
- CAS No.: 1197033-17-2
- Formula: C49H56N5O9P
- Molecular Weight:889.97
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite can be combined with other modified nucleotides (such as MOE, DNA) to synthesize chimeric antisense oligonucleotides (ASO)[1].
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite can be used to synthesize S-cEt-modified antisense oligonucleotides (ASO) D3 targeting mouse PTEN mRNA[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1197033-17-2
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Appearance Solid
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Molecular Weight 889.97
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Formula C49H56N5O9P
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Color White to off-white
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SMILES
CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C(N=C(C(C)=C2)NC(C3=CC=CC=C3)=O)=O)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 116.67 mg/mL (131.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1236 mL | 5.6182 mL | 11.2363 mL | 28.0908 mL |
| 5 mM | 0.2247 mL | 1.1236 mL | 2.2473 mL | 5.6182 mL | |
| 10 mM | 0.1124 mL | 0.5618 mL | 1.1236 mL | 2.8091 mL | |
| 15 mM | 0.0749 mL | 0.3745 mL | 0.7491 mL | 1.8727 mL | |
| 20 mM | 0.0562 mL | 0.2809 mL | 0.5618 mL | 1.4045 mL | |
| 25 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1236 mL | |
| 30 mM | 0.0375 mL | 0.1873 mL | 0.3745 mL | 0.9364 mL | |
| 40 mM | 0.0281 mL | 0.1405 mL | 0.2809 mL | 0.7023 mL | |
| 50 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5618 mL | |
| 60 mM | 0.0187 mL | 0.0936 mL | 0.1873 mL | 0.4682 mL | |
| 80 mM | 0.0140 mL | 0.0702 mL | 0.1405 mL | 0.3511 mL | |
| 100 mM | 0.0112 mL | 0.0562 mL | 0.1124 mL | 0.2809 mL |
5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite) Related Classifications
HY-148505 Related Classifications
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