5'-ODMT cEt m5U Phosphoramidite (Amidite)

Cat. No.: HY-148506 Purity: 99.76%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

5'-ODMT cEt m5U Phosphoramidite (Amidite) 화학구조

CAS No. : 1197033-22-9

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	견적 받기
1 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice^[1]^[2].

In Vitro

5′-methyl DNA modified ASOs exhibit excellent antisense activity^[2].
5'-ODMT cEt m5U Phosphoramidite Amidite (Compound 74) can be synthesized from the thymine-modified S-cEt nucleoside 62^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

786.85

화학식

C₄₂H₅₁N₄O₉P

CAS No.

1197033-22-9

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@]3(O[C@H]4N5C=C(C)C(NC5=O)=O)[C@@H](O[C@@]4([C@@H]3OP(N(C(C)C)C(C)C)OCCC#N)[H])C)C6=CC=CC=C6)C=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

용액&용해도

In Vitro:

DMSO : 125 mg/mL (158.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2709 mL	6.3545 mL	12.7089 mL
5 mM	0.2542 mL	1.2709 mL	2.5418 mL
10 mM	0.1271 mL	0.6354 mL	1.2709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

순도&문서

Purity: 99.76%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (260 KB) HNMR (323 KB) RP-HPLC (256 KB)

Handling Instructions (2659 KB)

References

[1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772.

[2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]

[3]. Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2709 mL	6.3545 mL	12.7089 mL	31.7723 mL
	5 mM	0.2542 mL	1.2709 mL	2.5418 mL	6.3545 mL
	10 mM	0.1271 mL	0.6354 mL	1.2709 mL	3.1772 mL
	15 mM	0.0847 mL	0.4236 mL	0.8473 mL	2.1182 mL
	20 mM	0.0635 mL	0.3177 mL	0.6354 mL	1.5886 mL
	25 mM	0.0508 mL	0.2542 mL	0.5084 mL	1.2709 mL
	30 mM	0.0424 mL	0.2118 mL	0.4236 mL	1.0591 mL
	40 mM	0.0318 mL	0.1589 mL	0.3177 mL	0.7943 mL
	50 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6354 mL
	60 mM	0.0212 mL	0.1059 mL	0.2118 mL	0.5295 mL
	80 mM	0.0159 mL	0.0794 mL	0.1589 mL	0.3972 mL
	100 mM	0.0127 mL	0.0635 mL	0.1271 mL	0.3177 mL