1197033-22-9
1197033-22-9
Chemical Structure
5'-ODMT cEt m5U Phosphoramidite (Amidite)
- CAS. Nr.: 1197033-22-9
- Formula:C42H51N4O9P
- Molecular Weight:786.85
InChIKey: SEFBXGXPINACNI-IMMRMUFKSA-N
SMILES: COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@]3(O[C@H]4N5C=C(C)C(NC5=O)=O)[C@@H](O[C@@]4([C@@H]3OP(N(C(C)C)C(C)C)OCCC#N)[H])C)C6=CC=CC=C6)C=C1
Biological Activity: 5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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5'-ODMT cEt m5U Phosphoramidite (Amidite) | 99.76% | 5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.91
HY-173193S-cEt-U phosphoramidite -
Similarity Score 0.90
HY-111531DMTr-LNA-5MeU-3-CED-phosphoramidite -
Similarity Score 0.84
HY-1500172'-O-Methyl-5-methyl-U CEP -
Similarity Score 0.84
HY-W7846145’-O-DMTr-2’-OMe-5MeU-CE (S)-phosphoramidite -
Similarity Score 0.82
HY-W570892DMTr-LNA-U-3-CED-Phosphora -
Similarity Score 0.82
HY-104016R2'-O-MOE-5MeU-3'-phosphoramidite (Standard) -
Similarity Score 0.81
HY-W570889DMT-LNA-5mA phosphoramidite -
Similarity Score 0.80
HY-W11217662'-O-(N-Methylcarbamoylmethyl)-5-Me-U-CE-phosphoramidite -
Similarity Score 0.80
HY-1546041-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite -
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References
- [1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772.
- [2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]
