6-Chloro-7-deazapurine-β-D-riboside

製品番号: HY-W054064 純度: 97.13%: Data Sheet SDS COA 取扱説明書
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6-Chloro-7-deazapurine-β-D-riboside, a nucleoside derivative, exerts antifungal effects. 6-Chloro-7-deazapurine-β-D-riboside shows activity against plant pathogenic fungi.

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6-Chloro-7-deazapurine-β-D-riboside 構造式

CAS 番号 : 16754-80-6

容量	価格（税別）	在庫状況	数量
100 mg	$30	在庫あり	Estimated Time of Arrival: December 31
250 mg	$45	在庫あり	Estimated Time of Arrival: December 31
1 g	$130	在庫あり	Estimated Time of Arrival: December 31
5 g	$495	在庫あり	Estimated Time of Arrival: December 31
10 g	$955	在庫あり	Estimated Time of Arrival: December 31
50 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

6-Chloro-7-deazapurine-β-D-riboside, a nucleoside derivative, exerts antifungal effects. 6-Chloro-7-deazapurine-β-D-riboside shows activity against plant pathogenic fungi^[1].

体外実験

6-Chloro-7-deazapurine-β-D-riboside (Compound 9) (20 ppm; 2-7 days) has activity against Cochliobolus miyabeanus, Pyricularia oryzae, Colletotricum lagenarium, and Phytophthora infestans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

285.69

分子式

C₁₁H₁₂ClN₃O₄

CAS 番号

16754-80-6

Appearance

Solid

Color

White to off-white

SMILES

ClC1=NC=NC2=C1C=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (350.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4.35 mg/mL (15.23 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5003 mL	17.5015 mL	35.0030 mL
5 mM	0.7001 mL	3.5003 mL	7.0006 mL
10 mM	0.3500 mL	1.7501 mL	3.5003 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (7.00 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.58%

Select Batch:

データシート (278 KB) SDS (394 KB)

COA (257 KB) HNMR (141 KB) RP-HPLC (369 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Hajime Iwamura, et al. Antifungal Activity of Substituted 7-(β-D-Ribofuranosyl)pyrrolo-[2,3-d]pyrimidines. Agricultural and Biological Chemistry, Volume 40, Issue 7, 1 July 1976, Pages

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.5003 mL	17.5015 mL	35.0030 mL	87.5074 mL
	5 mM	0.7001 mL	3.5003 mL	7.0006 mL	17.5015 mL
	10 mM	0.3500 mL	1.7501 mL	3.5003 mL	8.7507 mL
	15 mM	0.2334 mL	1.1668 mL	2.3335 mL	5.8338 mL
DMSO	20 mM	0.1750 mL	0.8751 mL	1.7501 mL	4.3754 mL
	25 mM	0.1400 mL	0.7001 mL	1.4001 mL	3.5003 mL
	30 mM	0.1167 mL	0.5834 mL	1.1668 mL	2.9169 mL
	40 mM	0.0875 mL	0.4375 mL	0.8751 mL	2.1877 mL
	50 mM	0.0700 mL	0.3500 mL	0.7001 mL	1.7501 mL
	60 mM	0.0583 mL	0.2917 mL	0.5834 mL	1.4585 mL
	80 mM	0.0438 mL	0.2188 mL	0.4375 mL	1.0938 mL
	100 mM	0.0350 mL	0.1750 mL	0.3500 mL	0.8751 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.