1. Immunology/Inflammation
  2. PGE synthase
  3. Limaprost

Limaprost (Synonyms: 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206)

製品番号: HY-B0683 純度: 99.95%
取扱説明書

Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。

Limaprost 構造式

Limaprost 構造式

CAS 番号 : 74397-12-9

容量 価格(税別) 在庫状況 数量
10 mM * 1  mL in DMSO USD 221 在庫あり
Estimated Time of Arrival: December 31
2 mg USD 132 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 264 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 492 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 1980 在庫あり
Estimated Time of Arrival: December 31
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment[1][2].

体外実験

Limaprost inhibits the IL-1-mediated induction of nerve growth factor (NGF) in a concentration-dependent manner with an IC50 value of 70.9  nM human IVD cells[3].

体内実験

Limaprost (OP1206) given orally at more than 100 mg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG)[1].
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential[1].
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg)[1].
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG[1].

臨床実験
分子量

380.52

分子式

C₂₂H₃₆O₅

CAS 番号

74397-12-9

SMILES

O=C(O)/C=C/CCCC[[email protected]@H]1[[email protected]@H](/C=C/[[email protected]@H](O)C[[email protected]@H](C)CCCC)[[email protected]](O)CC1=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 40 mg/mL (105.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6280 mL 13.1399 mL 26.2798 mL
5 mM 0.5256 mL 2.6280 mL 5.2560 mL
10 mM 0.2628 mL 1.3140 mL 2.6280 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献

純度: 99.95%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • モル濃度カルキュレーター

  • 希釈カルキュレーター

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Limaprost17α,20-dimethyl-δ2-PGE1ONO1206OP1206ONO 1206ONO-1206OP 1206OP-1206PGE synthaseProstaglandin E synthaseAntianginalplateletadhesionatheroscleroticADPaggregationvasodilatoralprostadilPGE1ischaemicIL-1Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

 

タイトル

お名前 *

 

PC 用メールアドレス *

電話番号 *

 

勤務先/学校名 *

Department *

 

カスタマ需要量 *

国会或いは地域 *

     

必ず会社名を記載ください。個人への返信は行いません。

メッセージ

バルクお問い合わせ

Inquiry Information

製品名:
Limaprost
製品番号:
HY-B0683
数量:
MCE 日本正規代理店: