1. Immunology/Inflammation
  2. PGE synthase
  3. Limaprost

Limaprost (Synonyms: 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206)

製品番号: HY-B0683 純度: 99.95%
取扱説明書

Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research.

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Limaprost 構造式

Limaprost 構造式

CAS 番号 : 74397-12-9

容量 価格(税別) 在庫状況 数量
Solution
10 mM * 1 mL in DMSO USD 221 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 221 在庫あり
Estimated Time of Arrival: December 31
Solid
2 mg USD 132 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 264 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 492 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 1980 在庫あり
Estimated Time of Arrival: December 31
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].

体外実験

Limaprost inhibits the IL-1-mediated induction of nerve growth factor (NGF) in a concentration-dependent manner with an IC50 value of 70.9  nM human IVD cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Limaprost (OP1206) given orally at more than 100 μg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG)[1].
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential[1].
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg)[1].
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験
分子量

380.52

分子式

C22H36O5

CAS 番号
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 40 mg/mL (105.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6280 mL 13.1399 mL 26.2798 mL
5 mM 0.5256 mL 2.6280 mL 5.2560 mL
10 mM 0.2628 mL 1.3140 mL 2.6280 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

*All of the co-solvents are available by MCE.
参考文献

純度: 99.95%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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製品名:
Limaprost
製品番号:
HY-B0683
数量:
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