1. Immunology/Inflammation
  2. PGE synthase
  3. Limaprost

Limaprost (Synonyms: 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206)

製品番号: HY-B0683 純度: 99.95%
取扱説明書

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor.

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Limaprost 構造式

Limaprost 構造式

CAS 番号 : 74397-12-9

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 221 在庫あり
Estimated Time of Arrival: December 31
2 mg USD 132 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 264 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 492 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 1980 在庫あり
Estimated Time of Arrival: December 31
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor. Target: Others Limaprost, an alprostadil (prostaglandin E1) analogue, is a vasodilator that increases blood flow and inhibits platelet aggregation. Limaprost is a n analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 mg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor, measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 mg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 mg/kg orally in rats [1].

臨床実験
分子量

380.52

分子式

C₂₂H₃₆O₅

CAS 番号

74397-12-9

SMILES

O=C(O)/C=C/CCCC[[email protected]@H]1[[email protected]@H](/C=C/[[email protected]@H](O)C[[email protected]@H](C)CCCC)[[email protected]](O)CC1=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 40 mg/mL (105.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6280 mL 13.1399 mL 26.2798 mL
5 mM 0.5256 mL 2.6280 mL 5.2560 mL
10 mM 0.2628 mL 1.3140 mL 2.6280 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献

純度: 99.95%

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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Limaprost17α,20-dimethyl-δ2-PGE1ONO1206OP1206ONO 1206ONO-1206OP 1206OP-1206PGE synthaseProstaglandin E synthaseInhibitorinhibitorinhibit

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Inquiry Information

製品名:
Limaprost
製品番号:
HY-B0683
数量:
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