1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Risdiplam

Risdiplam (Synonyms: RG7916; RO7034067)

製品番号: HY-109101 純度: 99.35%
取扱説明書

Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.

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Risdiplam 構造式

Risdiplam 構造式

CAS 番号 : 1825352-65-5

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製品説明

Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels[1].

IC50 & Target

SMN2

体外実験

Risdiplam modulates SMN2 pre-mRNA splicing towards the production of full-length SMN2 mRNA and increases SMN protein levels. Risdiplam is a modifier of SMN2 splicing, leading to an increase in SMN2 full length transcript and thus functional SMN protein. Spinal muscular atrophy (SMA) type I remains the most common genetic disease resulting in death in infancy. Characterized by progressive motor and respiratory muscle weakness, this autosomal recessive neuromuscular disorder is caused by low levels of the survival motor neuron protein (SMN) due to inactivating bi-allelic deletions and other disabling mutations in the survival motor neuron 1 (SMN1) gene[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験
分子量

401.46

分子式

C₂₂H₂₃N₇O

CAS 番号

1825352-65-5

SMILES

O=C(C=C(C(C=C1C)=NN2C1=NC(C)=C2)N=C3C=C4)N3C=C4N(CCN5)CC65CC6

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

Ethanol : 2 mg/mL (4.98 mM; Need ultrasonic)

DMSO : 2 mg/mL (4.98 mM; Need ultrasonic)

H2O : 1 mg/mL (2.49 mM; ultrasonic and warming and heat to 80°C)

*Risdiplam is usually formulated as a suspension.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4909 mL 12.4545 mL 24.9091 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
参考文献

純度: 99.35%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RisdiplamRG7916 RO7034067RG 7916RG-7916RO7034067RO 7034067RO-7034067DNA/RNA SynthesisInhibitorinhibitorinhibit

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製品名:
Risdiplam
製品番号:
HY-109101
数量:
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