1. Protein Tyrosine Kinase/RTK
  2. FGFR
  3. SUN11602

SUN11602 

Cat. No.: HY-101493 Purity: 99.10%
Handling Instructions

SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity.

For research use only. We do not sell to patients.

SUN11602 Chemical Structure

SUN11602 Chemical Structure

CAS No. : 704869-38-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 77 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity.

In Vitro

SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons[1]. SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression[2]. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate[1]. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

451.60

Formula

C₂₆H₃₇N₅O₂

CAS No.
SMILES

O=C(N)C1=CC=C(CN2CCC(N(C(CNC3=C(C)C(C)=C(N)C(C)=C3C)=O)C)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (81.93 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2143 mL 11.0717 mL 22.1435 mL
5 mM 0.4429 mL 2.2143 mL 4.4287 mL
10 mM 0.2214 mL 1.1072 mL 2.2143 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Cerebrocortical neurons are pretreated with vehicle (Hanks’ Balanced Salt Solution), SUN11602, bFGF, or the other growth factors for 24 h prior to the onset of glutamate toxicity. Subsequently, 10 μL of the MTT solution (5 mg/mL) is added to each well (200 μL of culture medium) of the microplates. Neurons in each well are then dried for 24 h, and 200 μL of DMSO is poured into all of the wells in order to dissolve the reaction products thoroughly for the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Rats: SUN11602 (0.1,1,and10mg/kg)is administered orally to the rat hippocampal-lesion model, once at 24 h after the Aβ1–40 injection. In the vehicle-treated groups, saline is administered instead of SUN11602[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

SUN11602SUN 11602SUN-11602FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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