2. Vías de señalización
  3. GPCR/G Protein
  4. Angiotensin Receptor
  5. AT2 Receptor Isoform
  6. AT2 Receptor Agonist

AT2 Receptor Agonist

AT2 Receptor Agonists (5):

Cat. No. Nombre del producto Efecto Pureza
  • HY-100113
    Buloxibutid
    		Agonist 98.94%
    Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis.
  • HY-100113A
    Buloxibutid hydrochloride
    		Agonist
    Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions.
  • HY-P1540
    Angiotensin III, human, mouse
    		Agonist 98.26%
    Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
  • HY-P0080
    Novokinin
    		Agonist 99.38%
    Novokinin is a peptide agonist of the angiotensin AT2 receptor.
  • HY-P0080A
    Novokinin TFA
    		Agonist
    Novokinin TFA is a peptide agonist of the angiotensin AT2 receptor.