Angiotensin III, human, mouse

Name: Angiotensin III, human, mouse
Brand: MedChemExpress
SKU: HY-P1540
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1540 Purity: 99.40%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin III, human, mouse Chemical Structure

CAS No. : 13602-53-4

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 185	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Angiotensin III, human, mouse:

Angiotensin III, human, mouse TFA In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.648 nM (AT₂R), 21.1 nM (AT₁R)^[1]

In Vitro

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (U_NaV), fractional excretion of sodium (FE_Na), and fractional excretion of lithium (FE_Li) in SD rat^[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

931.09

Formula

C₄₆H₆₆N₁₂O₉

CAS No.

13602-53-4

Appearance

Solid

Color

White to off-white

Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

Sequence Shortening

RVYIHPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (107.40 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0740 mL	5.3700 mL	10.7401 mL
5 mM	0.2148 mL	1.0740 mL	2.1480 mL
10 mM	0.1074 mL	0.5370 mL	1.0740 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.40%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (252 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. [Content Brief]

[2]. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. [Content Brief]

[3]. Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0740 mL	5.3701 mL	10.7401 mL	26.8503 mL
	5 mM	0.2148 mL	1.0740 mL	2.1480 mL	5.3701 mL
	10 mM	0.1074 mL	0.5370 mL	1.0740 mL	2.6850 mL
	15 mM	0.0716 mL	0.3580 mL	0.7160 mL	1.7900 mL
	20 mM	0.0537 mL	0.2685 mL	0.5370 mL	1.3425 mL
	25 mM	0.0430 mL	0.2148 mL	0.4296 mL	1.0740 mL
	30 mM	0.0358 mL	0.1790 mL	0.3580 mL	0.8950 mL
	40 mM	0.0269 mL	0.1343 mL	0.2685 mL	0.6713 mL
	50 mM	0.0215 mL	0.1074 mL	0.2148 mL	0.5370 mL
	60 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.4475 mL
	80 mM	0.0134 mL	0.0671 mL	0.1343 mL	0.3356 mL
	100 mM	0.0107 mL	0.0537 mL	0.1074 mL	0.2685 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.