Angiotensin III, human, mouse
Based on 1 Customer Validation
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
For research use only. We do not sell to patients.
- Purity: 98.26%
- CAS No.: 13602-53-4
- Formula: C46H66N12O9
- Molecular Weight:931.09
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Angiotensin Receptor Isoforms
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Biological Activity
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AT2 Receptor |
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13602-53-4
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Appearance Solid
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Molecular Weight 931.09
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Formula C46H66N12O9
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Color White to off-white
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Sequence
Arg-Val-Tyr-Ile-His-Pro-Phe
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Sequence Shortening
RVYIHPF
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (107.40 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. [Content Brief]
[2]. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. [Content Brief]
[3]. Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0740 mL | 5.3701 mL | 10.7401 mL | 26.8503 mL |
| 5 mM | 0.2148 mL | 1.0740 mL | 2.1480 mL | 5.3701 mL | |
| 10 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6850 mL | |
| 15 mM | 0.0716 mL | 0.3580 mL | 0.7160 mL | 1.7900 mL | |
| 20 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3425 mL | |
| 25 mM | 0.0430 mL | 0.2148 mL | 0.4296 mL | 1.0740 mL | |
| 30 mM | 0.0358 mL | 0.1790 mL | 0.3580 mL | 0.8950 mL | |
| 40 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.6713 mL | |
| 50 mM | 0.0215 mL | 0.1074 mL | 0.2148 mL | 0.5370 mL | |
| 60 mM | 0.0179 mL | 0.0895 mL | 0.1790 mL | 0.4475 mL | |
| 80 mM | 0.0134 mL | 0.0671 mL | 0.1343 mL | 0.3356 mL | |
| 100 mM | 0.0107 mL | 0.0537 mL | 0.1074 mL | 0.2685 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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