1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2 Isoform
  5. Bcl-2 Antagonist

Bcl-2 Antagonist

Bcl-2 Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-13407
    Antagonist 99.56%
    Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
  • HY-101083
    BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells.