MAGL
Monoacylglycerol lipase
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty acids. MAGL links the endocannabinoid and eicosanoid systems together by degradation of the abundant endocannabinoid 2-arachidaoylglycerol into arachidonic acid, the precursor of prostaglandins and other inflammatory mediators.
MAGL plays a critical role in lipid signalling: i) it is the major enzyme that controls the levels of 2-AG, an important lipid with various neuroprotective effects; ii) inactivation of MAGL induces an elevation in brain levels of 2-AG and a reduction of AA, a key precursor of pro-inflammatory prostaglandins, resulting in the reduction of neuroinflammation; iii) MAGL regulates the levels of free fatty acids (FFAs) in aggressive cancer cells, and this MAGL-promoted fatty acid network drives a number of pro-tumorigenic signalling pathways. MAGL is emerging as a promising drug target for various diseases.
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MAGL Related Products (86)
Related Products (86)
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FAAH/MAGL-IN-2
0 ImagesCat. No.: HY-143264CAS No.: 2765077-82-3
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OMDM169
0 ImagesCat. No.: HY-120560CAS No.: 130193-44-1
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DH-376
0 ImagesCat. No.: HY-120171CAS No.: 1848233-57-7DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice. DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Dimepiperate
0 ImagesCat. No.: HY-116793CAS No.: 61432-55-1Synonyms: MY 93; YukamateDimepiperate (MY 93) is a thiocarbamate (TC) pesticide. Dimepiperate has potential off-targets effect for the inhibition of ABHD6.
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FAAH-IN-5
0 ImagesCat. No.: HY-146341CAS No.: 1338575-38-4FAAH-IN-5 (Compound 7) is a relative selective, irreversible fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 10.5 nM. FAAH-IN-5 shows low PAMPA (Parallel Artificial Membrane Permeability Assay) permeability.
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MAGL-IN-17
0 ImagesCat. No.: HY-124378CAS No.: 1643657-35-5MAGL-IN-17 (Compound ) is an inhibitor for MAGL with a Ki of 0.4 μM. MAGL-IN-17 inhibits mouse MAGL and rat MAGL with IC50 of 0.18 and 0.24 μM. MAGL-IN-17 exhibits anti-inflammatory activity in mouse experimental autoimmune encephalitis models.
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MAGL-IN-14
0 ImagesCat. No.: HY-162304CAS No.: 2770967-04-7MAGL-IN-14 (compound 2) is a potent inhibitor of MAGL, with IC50 of 0.00289 μM and 0.002 μM in HEK293 and PC3 cells, respectively.
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MAGL-IN-18
0 ImagesCat. No.: HY-168032CAS No.: 3036792-74-9
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MAGL-IN-6
0 ImagesCat. No.: HY-145945CAS No.: 2414320-29-7MAGL-IN-6 is a potent MAGL inhibitor with an IC50 of 4.71 nM. MAGL-IN-6 can be used for neurological disorders research (WO2020065613A1; example 234).
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ABD-1970
0 ImagesCat. No.: HY-124576CAS No.: 2010154-82-0
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MAGL-IN-15
0 ImagesCat. No.: HY-162305CAS No.: 2770967-08-1MAGL-IN-15 (Compound 6) is a MAGL inhibitor that can be used in the research of diseases and disorders related to the regulation of endocannabinoid system signaling activities.
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JJKK 048 (Standard)
0 ImagesCat. No.: HY-108613RCAS No.: 1515855-97-6JJKK 048 (Standard) is the analytical standard of JJKK 048 (HY-108613). This product is intended for research and analytical applications. JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain.
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JW 642 (Standard)
0 ImagesJW 642 (Standard) is the analytical standard of JW 642. This product is intended for research and analytical applications.
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MAGL-IN-11
0 ImagesCat. No.: HY-157042CAS No.: 3017151-84-4MAGL-IN-11 (compound 29) is a selective and reversible MAGL inhibitor. MAGL-IN-11 has the potential to study inflammation, cancer and antioxidants.
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MAGL-IN-1 (Standard)
0 ImagesCat. No.: HY-111538RCAS No.: 2324160-91-8MAGL-IN-1 (Standard) is the analytical standard of MAGL-IN-1 (HY-111538). This product is intended for research and analytical applications. MAGL-IN-1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL-IN-1 exhibits anti-proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL-IN-1 blocks MAGL in cell-based as well as in vivo assays.
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JZP-430 (Standard)
0 ImagesCat. No.: HY-101457RCAS No.: 1672691-74-5JZP-430 (Standard) is the analytical standard of JZP-430 (HY-101457). This product is intended for research and analytical applications. JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
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MAGL-IN-10
0 ImagesCat. No.: HY-157041CAS No.: 3017151-83-3
