MAGL-IN-17
MAGL-IN-17 (Compound ) is an inhibitor for MAGL with a Ki of 0.4 μM. MAGL-IN-17 inhibits mouse MAGL and rat MAGL with IC50 of 0.18 and 0.24 μM. MAGL-IN-17 exhibits anti-inflammatory activity in mouse experimental autoimmune encephalitis models.
For research use only. We do not sell to patients.
- CAS No.: 1643657-35-5
- Formula: C26H26O4
- Molecular Weight:402.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Ki: 0.4 μM (MAGL)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caov-3 cell line | IC50 |
>200 μM
Compound: 3
|
Antiproliferative activity against human Caov-3 cells assessed as reduction in cell viability incubated for 96 hrs by Cell-titer-Glo luminescent cell viability assay
Antiproliferative activity against human Caov-3 cells assessed as reduction in cell viability incubated for 96 hrs by Cell-titer-Glo luminescent cell viability assay
|
[PMID: 27809504] |
| MRC5 | IC50 |
>200 μM
Compound: 3
|
Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability incubated for 96 hrs by Cell-titer-Glo luminescent cell viability assay
Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability incubated for 96 hrs by Cell-titer-Glo luminescent cell viability assay
|
[PMID: 27809504] |
| OVCAR-3 | IC50 |
110 μM
Compound: 3
|
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 96 hrs by Cell-titer-Glo luminescent cell viability assay
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 96 hrs by Cell-titer-Glo luminescent cell viability assay
|
[PMID: 27809504] |
Chemical Information
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CAS No. 1643657-35-5
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Molecular Weight 402.48
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Formula C26H26O4
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SMILES
O=C(CCCCCC1=CC=C(C2=CC=CC=C2)C=C1)OCC3=CC4=C(C=C3)OCO4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)