NLRP3 Modulator

NLRP3 modulator 7 (Compound 17B) is a NLRP3 inflammasome modulator. NLRP3 modulator 7 inhibits LPS (HY-D1056)-induced IL-1β release in fresh human whole blood. NLRP3 modulator 7 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling.

Benzylurea is an anti-inflammatory agent. Benzylurea inhibits LPS (HY-D1056)-induced upregulation of MTCH2 expression and regulates pathways associated with mitochondrial function, inflammation and cell survival. Benzylurea alleviates LPS-induced proliferation inhibition and apoptosis of periodontal ligament fibroblasts, as well as the release of proinflammatory cytokines. Benzylurea can be used in studies related to periodontitis.

NLRP3 modulator 1 is the potent modulator of NLRP3. NLRP3 modulator 1 agonizes or partially agonizes NLRP3 that are useful for researching a condition, disease or disorder in which a decrease in LRP3 activity contributes to the pathology (extracted from patent WO2017184746A1, compound 107).

Abdenoflast (Compound 12) is an NLRP3 modulator with an IL-1β inhibitory IC₅₀ < 1 μM in human whole blood.

NLRP3 modulator 7 (Compound 17B) TFA is a NLRP3 inflammasome modulator. NLRP3 modulator 7 TFA inhibits LPS (HY-D1056)-induced IL-1β release in fresh human whole blood. NLRP3 modulator 7 TFA can be used in studies related to NLRP3 inflammasome activation and innate immune signaling.