Neprilysin
Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10
Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.
Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.
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Neprilysin 関連製品 (70)
関連製品 (70)
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組換えタンパク質 (2)
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Sacubitril-d5 hemicalcium
0 Images製品番号: HY-15407AS2別名: AHU-377-d5 hemicalciumSacubitril-d5 (AHU-377-d5) hemicalcium is deuterium-labeled Sacubitril hemicalcium (HY-15407A).
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SCH 42495 racemate
0 Images製品番号: HY-101682ACAS 番号: 145841-10-7SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
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SCH-34826
0 Images製品番号: HY-19063CAS 番号: 105262-04-2SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that inhibits NEP and reduces the degradation of ANF, thereby enhancing its antihypertensive and diuretic effects. SCH-34826 can be used in the research of cardiovascular and renal diseases.
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Alatrioprilat
0 Images製品番号: HY-117607CAS 番号: 135038-59-4Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases.
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Phenylalanylalanine (Standard)
0 Images別名: Phe-ala (Standard)Phenylalanylalanine (Standard) (Phe-ala (Standard)) is the analytical standard of Phenylalanylalanine (HY-W009602). This product is intended for research and analytical applications. Phenylalanylalanine is an enkephalinase inhibitor and belongs to the class of dipeptides. Phenylalanylalanine inhibits dipeptidyl carboxypeptidase-mediated enkephalin degradation by cleaving the Gly3-Phe4 bond, and when co-administered with Leu-enkephalin, it produces analgesic effects with a synergistic enhancement, which can be reversed by Naloxone (HY-17417A). Phenylalanylalanine can be used in pain-related research.
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Racecadotril (Standard)
0 Images別名: Acetorphan (Standard)Racecadotril (Standard) is the analytical standard of Racecadotril. This product is intended for research and analytical applications. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
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NEP-In-1
0 Images製品番号: HY-U00294CAS 番号: 465527-94-0NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.
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SCH 42495
0 Images製品番号: HY-101682CAS 番号: 136511-43-8SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
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SQ28603
0 Images製品番号: HY-U00171CAS 番号: 100845-83-8別名: SQ28,603; Squibb 28603SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
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NEP-IN-2
0 Images製品番号: HY-U00336CAS 番号: 145775-14-0NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.
