Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2435)
Related Products (2435)
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N6-(3-Trifluoromethylbenzyl)-2’-C-methyl adenosine
0 ImagesCat. No.: HY-152402CAS No.: 2305415-78-3N6-(3-Trifluoromethylbenzyl)-2’-C-methyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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6-(2-Furanyl)-9-β-D-ribofuranosyl-9H-purine
0 ImagesCat. No.: HY-152808CAS No.: 352025-81-16-(2-Furanyl)-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-Deoxy-5’-(4-morpholinyl)thymidine
0 ImagesCat. No.: HY-154568CAS No.: 2305415-93-25’-Deoxy-5’-(4-morpholinyl)thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Beta-C-Methyl-inosine
0 ImagesCat. No.: HY-1524113’-Beta-C-Methyl-inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-O-Benzoyl-3-O-t-butyldiphenylsilyl-L-threono lactone
0 ImagesCat. No.: HY-154218CAS No.: 1446785-28-92-O-Benzoyl-3-O-t-butyldiphenylsilyl-L-threono lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6,N6-Dimethyl-xylo-adenosine
0 ImagesCat. No.: HY-152357CAS No.: 669055-52-1N6,N6-Dimethyl-xylo-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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3’-Deoxy-3’-fluoro-5-fluorouridine
0 ImagesCat. No.: HY-152760CAS No.: 112668-56-13’-Deoxy-3’-fluoro-5-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside
0 ImagesCat. No.: HY-152746CAS No.: 2095417-35-72-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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2’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-methoxy uridine
0 ImagesCat. No.: HY-154145CAS No.: 2072145-79-82’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-methoxy uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-O-DMTr-3’-deoxyuridine
0 ImagesCat. No.: HY-154237CAS No.: 86234-42-65’-O-DMTr-3’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine
0 ImagesCat. No.: HY-112120CAS No.: 1612192-05-82-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine ((2R,3S,4S,5R)-2-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2′,3′-O-Isopropylideneisocytidine
0 ImagesCat. No.: HY-W556301CAS No.: 5975-05-32′,3′-O-Isopropylideneisocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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4’,5’-Didehydro-2’-O-(2-methoxyethyl)-5-methyluridine
0 ImagesCat. No.: HY-154385CAS No.: 2095417-31-34’,5’-Didehydro-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Amino-2’-deoxy-5-methyl uridine
0 ImagesCat. No.: HY-152435CAS No.: 869729-38-42’-Amino-2’-deoxy-5-methyl uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N1,N2-Dimethyl-2’-O-methylguanosine
0 ImagesCat. No.: HY-152545CAS No.: 2305416-05-9N1,N2-Dimethyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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Adenosine-d-1
0 ImagesSynonyms: Adenine riboside-d1-1; D-Adenosine-d-1
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22-Oxodocosanoic acid
0 ImagesCat. No.: HY-180678CAS No.: 1034470-39-722-Oxodocosanoic acid is a nucleoside metabolite.
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3’-Azido-3’-deoxy-5-fluoro-beta-L-cytidine
0 ImagesCat. No.: HY-152597CAS No.: 2095417-76-63’-Azido-3’-deoxy-5-fluoro-beta-L-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-fluoro-beta-L-cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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5-Hydroxykynurenine
0 ImagesCat. No.: HY-180726CAS No.: 16547-59-45-Hydroxykynurenine is a nucleoside metabolite.
