Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
All Product Categories
-
Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
-
5'-O-DMTr-2'-O-methyl-N6-methyl adenosine 3'-CED phosphoramidite
0 ImagesCat. No.: HY-154485CAS No.: 2348385-04-45'-O-DMTr-2'-O-methyl-N6-methyl adenosine 3'-CED phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
-
LY207702
0 ImagesCat. No.: HY-117361CAS No.: 103828-81-5LY207702 is a difluorinated purine nucleoside with antitumor activity and cardiotoxicity. LY207702 is cytotoxic to CEA-positive LS174T cells (IC50=0.302 μg/mL). LY207702 can be used in the study of colon cancer.
-
2′,3′-Dideoxy-5-fluorouridine
0 ImagesCat. No.: HY-154556CAS No.: 15379-30-32′,3′-Dideoxy-5-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
N1-Methyl-2’-beta-C-methyl adenosine
0 ImagesCat. No.: HY-152509N1-Methyl-2’-beta-C-methyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
Thiamiprine
0 ImagesThiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
-
9-(2-β-C-Methyl-β-D-ribofuranosyl)purine
0 ImagesCat. No.: HY-152805CAS No.: 690269-86-49-(2-β-C-Methyl-β-D-ribofuranosyl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
7-n-Butyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
0 ImagesCat. No.: HY-152333CAS No.: 2389988-45-67-n-Butyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3’-O-Methyl-2’-O-acetyl-5’-O-benzoyluridine
0 ImagesCat. No.: HY-154729CAS No.: 2072145-71-03’-O-Methyl-2’-O-acetyl-5’-O-benzoyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
Rev 2’-O-MOE-C(Bz)-5’-amidite
0 ImagesCat. No.: HY-154230Rev 2’-O-MOE-C(Bz)-5’-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
2-Trifluoromethyl adenosine
0 Images2-Trifluoromethyl adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
2',3',5'-Tri-O-benzoyl-5-azacytidine
0 ImagesCat. No.: HY-154397CAS No.: 28998-36-9
-
4α-Methylfecosterol
0 ImagesCat. No.: HY-180651CAS No.: 17757-07-24α-Methylfecosterol is an unsaponifiable lipid.
-
5-(Hydroxymethyl)-2′,3′-O-(1-methylethylidene)uridine
0 ImagesCat. No.: HY-W552067CAS No.: 3816-77-1
-
Sp-dCTPαS tetrasodium
0 ImagesCat. No.: HY-137619A
-
5-Methoxy cytidine
0 ImagesCat. No.: HY-W400159CAS No.: 37805-90-6
-
N1-Methylsulfonyl pseudouridine
0 ImagesCat. No.: HY-152323N1-Methylsulfonyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
1-(2,3,5-Tri-O-benzoyl-2-C-β-methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one
0 ImagesCat. No.: HY-152974CAS No.: 2072145-38-91-(2,3,5-Tri-O-benzoyl-2-C-β-methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a nitropyridine nucleoside analogue.
-
3’,4-Dideoxyuridine
0 ImagesCat. No.: HY-154474CAS No.: 2095417-04-03’,4-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
0 ImagesCat. No.: HY-180750CAS No.: 2129640-47-55-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde is a nucleoside metabolite.
-
8-Bromoguanosine-13C,15N2
0 ImagesCat. No.: HY-W7673718-Bromoguanosine-13C,15N2 is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function.
