Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2436)
Related Products (2436)
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5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
0 ImagesCat. No.: HY-180750CAS No.: 2129640-47-55-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde is a nucleoside metabolite.
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8-Bromoguanosine-13C,15N2
0 ImagesCat. No.: HY-W7673718-Bromoguanosine-13C,15N2 is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function.
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1-Amino-7-cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
0 ImagesCat. No.: HY-152432CAS No.: 2389988-22-91-Amino-7-cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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(R)-Ureidoisobutyric acid
0 ImagesCat. No.: HY-113211ACAS No.: 1315050-26-0(R)-Ureidoisobutyric acid is a nucleoside metabolite.
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2′-O-Methyl-2-amino-6-chloropurine riboside
0 ImagesCat. No.: HY-152876CAS No.: 194034-59-86-Chloro-9-(2-O-methyl-beta-D-ribofuranosyl)-9H-purin-2-amine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N1-Methyl-2’-deoxy-2’-fluoroarabinoadenosine
0 ImagesCat. No.: HY-152481N1-Methyl-2’-deoxy-2’-fluoroarabinoadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-Methyl-3’-O-(2-methoxyethyl) adenosine
0 ImagesCat. No.: HY-152575N6-Methyl-3’-O-(2-methoxyethyl) adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-C-Methylguanosine
0 ImagesSynonyms: 2'-C-beta-Methylguanosine2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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3’-beta-C-Methyladenosine
0 ImagesCat. No.: HY-152366CAS No.: 15397-13-43′-β-C-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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4’-C-Methyl-4-deoxyuridine
0 ImagesCat. No.: HY-152548CAS No.: 1064364-21-14’-C-Methyl-4-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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(R)-2-Hydroperoxy-α-linolenic acid
0 ImagesCat. No.: HY-180676CAS No.: 248243-14-3(R)-2-Hydroperoxy-α-linolenic acid is a nucleoside metabolite.
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2’-Deoxy-2’-fluoro-6-S-Methyl-6-thio-ara-guanosine
0 ImagesCat. No.: HY-152532CAS No.: 109304-11-22’-Deoxy-2’-fluoro-6-S-Methyl-6-thio-ara-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Hydroxy-2’-O-methyluridine
0 ImagesCat. No.: HY-152377CAS No.: 2030403-78-05-Hydroxy-2’-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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6-(2-O-Methyl-beta-D-ribofuranosyl)-3-(2-oxo-propyl)-6H-imidazo[1,2-c]pyrimidin-5-one
![6-(2-O-Methyl-beta-D-ribofuranosyl)-3-(2-oxo-propyl)-6H-imidazo[1,2-c]pyrimidin-5-one](https://file.medchemexpress.com/product_pic/hy-152770.gif "Click to View 6-(2-O-Methyl-beta-D-ribofuranosyl)-3-(2-oxo-propyl)-6H-imidazo[1,2-c]pyrimidin-5-one Product Detail")
0 ImagesCat. No.: HY-152770CAS No.: 2095417-54-06-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-3-(2-oxopropyl)imidazo[1,2-c]pyrimidin-5(6H)-one is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
0 ImagesCat. No.: HY-180774CAS No.: 857760-67-94-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid is a nucleoside metabolite.
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3’-N-Acetyl-3’-amino-3’-deoxyuridine
0 ImagesCat. No.: HY-152618CAS No.: 2305415-89-63’-N-Acetyl-3’-amino-3’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3-Benzylmalic acid
0 ImagesCat. No.: HY-180728CAS No.: 17222-20-7Synonyms: 3-Benzylmalate3-Benzylmalic acid (3-Benzylmalate) can be converted from 2-Benzylmalic acid through a HphCD-mediated hydroxyl isomerization reaction.
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5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine
![5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine](https://file.medchemexpress.com/product_pic/hy-154198.gif "Click to View 5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine Product Detail")
0 ImagesCat. No.: HY-154198CAS No.: 112897-99-15′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’,5’-Di-O-acetyl-2’-deoxy-N3-methyl uridine
0 ImagesCat. No.: HY-154561CAS No.: 2305416-14-03’,5’-Di-O-acetyl-2’-deoxy-N3-methyl uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Azido-3’-deoxy-N6-methyladenosine
0 ImagesCat. No.: HY-152315CAS No.: 889126-08-33’-Azido-3’-deoxy-N6-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-N6-methyladenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
