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Cat. No.: HY-152366

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3’-beta-C-Methyladenosine

3′-β-C-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

For research use only. We do not sell to patients.

CAS No.: 15397-13-4
Formula: C₁₁H₁₅N₅O₄
Molecular Weight:281.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

3’-beta-C-Methyladenosine Chemical Structure

CAS No.: 15397-13-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	GI₅₀	23.2 μM Compound: 3'-Me-Ado	Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay	[PMID: 18588281]
Caco-2	GI₅₀	24.3 μM Compound: 3'-Me-Ado	Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay	[PMID: 21349610]
Caco-2	IC₅₀	24.3 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human Caco2 cells after 48 hrs by MTT assay Growth inhibition of human Caco2 cells after 48 hrs by MTT assay	[PMID: 25304896]
HeLa	GI₅₀	23.3 μM Compound: 3'-Me-Ado	Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay	[PMID: 21349610]
HeLa	IC₅₀	23.3 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 25304896]
HL-60	IC₅₀	15 μM Compound: 5, 3'-Me-Ado	Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method	[PMID: 25304896]
HL-60	IC₅₀	15.6 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HL60 cells after 48 hrs by MTT assay Growth inhibition of human HL60 cells after 48 hrs by MTT assay	[PMID: 25304896]
HT-29	GI₅₀	26.1 μM Compound: 3'-Me-Ado	Antitumor activity against human HT29 cells after 48 hrs by MTS assay Antitumor activity against human HT29 cells after 48 hrs by MTS assay	[PMID: 18588281]
HT-29	GI₅₀	26.1 μM Compound: 3'-Me-Ado	Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 21349610]
HT-29	IC₅₀	23.2 μM Compound: 3 (3'-Me-Ado)	In vitro inhibitory activity against human colon carcinoma HT-29 cell line In vitro inhibitory activity against human colon carcinoma HT-29 cell line	[PMID: 16033277]
HT-29	IC₅₀	26.1 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HT-29 cells after 48 hrs by MTT assay Growth inhibition of human HT-29 cells after 48 hrs by MTT assay	[PMID: 25304896]
HuT78	IC₅₀	17.3 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HUT78 cells after 48 hrs by MTT assay Growth inhibition of human HUT78 cells after 48 hrs by MTT assay	[PMID: 25304896]
K562	GI₅₀	9.4 μM Compound: 3'-Me-Ado	Antitumor activity against human K562 cells after 48 hrs by MTS assay Antitumor activity against human K562 cells after 48 hrs by MTS assay	[PMID: 18588281]
K562	GI₅₀	9.4 μM Compound: 3'-Me-Ado	Antiproliferative activity against human K562 cells after 72 hrs by MTS assay Antiproliferative activity against human K562 cells after 72 hrs by MTS assay	[PMID: 21349610]
K562	IC₅₀	18.2 μM Compound: 3 (3'-Me-Ado)	In vitro inhibitory activity against human myelogenous leukemia K562 cell line In vitro inhibitory activity against human myelogenous leukemia K562 cell line	[PMID: 16033277]
K562	IC₅₀	38.3 μM Compound: 3 (3'-Me-Ado)	In vitro inhibitory activity against human leukemia K562IU cell line In vitro inhibitory activity against human leukemia K562IU cell line	[PMID: 16033277]
K562	IC₅₀	9.4 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human K562 cells after 48 hrs by MTT assay Growth inhibition of human K562 cells after 48 hrs by MTT assay	[PMID: 25304896]
MCF7	GI₅₀	22.4 μM Compound: 3'-Me-Ado	Antitumor activity against human MCF7 cells after 48 hrs by MTS assay Antitumor activity against human MCF7 cells after 48 hrs by MTS assay	[PMID: 18588281]
MCF7	GI₅₀	22.4 μM Compound: 3'-Me-Ado	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 21349610]
MCF7	IC₅₀	17.5 μM Compound: 3 (3'-Me-Ado)	In vitro inhibitory activity against human breast carcinoma MCF-7 cell line In vitro inhibitory activity against human breast carcinoma MCF-7 cell line	[PMID: 16033277]
MCF7	IC₅₀	22.4 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 25304896]

Chemical Information

CAS No. 15397-13-4
Molecular Weight 281.27
Formula C₁₁H₁₅N₅O₄
SMILES

C[C@]1(O)[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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