PGE synthase
Prostaglandin E synthase
PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) to PGE2, is known to comprise a group of at least three structurally and biologically distinct enzymes. There are membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).
mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX-1. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. cPGES is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE2 production.
All Product Categories
-
PGE synthase Related Products (127)
Related Products (127)
-
Antibodies (2)
-
T26A
0 ImagesCat. No.: HY-177440CAS No.: 958860-12-3T26A is a highly selective prostaglandin transporter (PGT) inhibitor.T26A does not interact with the PGT homolog OATPc, blocks PGT-mediated PGE2 influx, and blocks PGE2 metabolism.T26A retains PGE2 in the extracellular compartment and reduces intracellular PGE2 metabolites.T26A elevates circulating endogenous PGE2 levels, reduces circulating endogenous PGE2 metabolite levels, and slows metabolism of exogenously injected PGE2 in Rattus norvegicus via intravenous injection.T26A does not affect PGE2 synthesis.T26A can be used for the research of PGT function in adult animals.
-
Isofezolac
0 ImagesCat. No.: HY-105939CAS No.: 50270-33-2Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties.
-
Limaprost-d3
0 ImagesCat. No.: HY-B0683SCAS No.: 1263190-37-9Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research.
-
KH176m
0 ImagesCat. No.: HY-128795CAS No.: 2095304-61-1KH176m is the major active metabolite of KH176 (HY-121577). KH176m is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor that can cross the blood-brain barrier, with an IC50 of 0.16 µM against mouse mPGES-1 and 1.51 µM against human mPGES-1. KH176m blocks LPS- or IL-1β-induced PGE2 production, scavenges ROS, inhibits lipid peroxidation, accelerates NADPH consumption, suppresses the growth of prostate cancer spheroids, reduces the CD44+ CD24− prostate cancer stem cell population, and protects fibroblasts with oxidative phosphorylation defects from redox stress-induced death. KH176m can be used in research related to mitochondrial diseases, inflammatory pain, inflammatory neurological diseases, inflammatory cancers, and prostate cancer.
-
Benzydamine
0 ImagesBenzydamine is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells.
-
Pranoprofen (Standard)
0 ImagesPranoprofen (Standard) is the analytical standard of Pranoprofen. This product is intended for research and analytical applications. Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
-
(Z)-Broparestrol
0 ImagesCat. No.: HY-187157CAS No.: 22393-63-1(Z)-Broparestrol is a prostaglandin synthetase inhibitor with an IC50 of 7.0 μM in cattle. (Z)-Broparestrol inhibits prostaglandin synthetase activity in bovine seminal vesicle microsomes. (Z)-Broparestrol is applicable for acne-related research.
