PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4103)
Related Products (4103)
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PROTAC Linkers Isoform Comparison
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Desthiobiotin-PEG4-propargyl
0 ImagesCat. No.: HY-W096125CAS No.: 1951424-89-7
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Mal-amido-PEG12-NHS ester
0 ImagesCat. No.: HY-140977CAS No.: 2101722-60-3
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Amino-PEG9-acid
0 ImagesAmino-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG9-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Aminooxy-PEG5-azide
0 ImagesAminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Propargyl-PEG7-alcohol
0 ImagesCat. No.: HY-130378CAS No.: 1422023-54-8
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Propargyl-PEG6-NHS ester
0 ImagesPropargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG6-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Bromo-PEG7-Boc
0 ImagesCat. No.: HY-134677CAS No.: 2766000-37-5
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Dde Biotin-PEG4-DBCO
0 ImagesCat. No.: HY-140931CAS No.: 1807512-43-1
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Tetraethylene glycol monotosylate
0 ImagesCat. No.: HY-41541CAS No.: 77544-60-6Synonyms: Tos-PEG4Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
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Me-PEG4-Me
0 ImagesSynonyms: Tetraglyme
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Azido-PEG12-NHS ester
0 ImagesAzido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bromo-PEG5-bromide
0 ImagesCat. No.: HY-141374CAS No.: 67705-77-5
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m-PEG4-azide
0 ImagesSynonyms: 13-Azido-2,5,8,11-tetraoxatridecanem-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Boc-N-bis(PEG4-acid)
0 ImagesCat. No.: HY-140540CAS No.: 2093152-88-4
