PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Amino-PEG7-t-butyl ester
0 ImagesAmino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG7-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). Amino-PEG7-t-butyl ester can be used in drug delivery research.
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Amino-PEG5-C2-acid
0 ImagesCat. No.: HY-115384CAS No.: 1191078-74-6Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Diazo Biotin-PEG3-azide
0 ImagesCat. No.: HY-140918CAS No.: 1339202-33-3Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azide-PEG12-alcohol
0 ImagesAzide-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG12-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Methyl 6-hydroxyhexanoate
0 ImagesCat. No.: HY-W129389CAS No.: 4547-43-7
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Benzyl (3-bromopropyl)carbamate
0 ImagesCat. No.: HY-W105943CAS No.: 39945-54-5
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(9H-Fluoren-9-yl)methyl (4-aminobutyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W097266CAS No.: 321660-77-9
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16-Bromo-1-hexadecanol
0 ImagesCat. No.: HY-W093045CAS No.: 59101-28-9
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3-(3-Aminopropoxy)propan-1-ol
0 ImagesCat. No.: HY-W096101CAS No.: 118273-16-8
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(1-Boc-4-piperidinyloxy)acetic acid
0 ImagesCat. No.: HY-W001460CAS No.: 161948-70-5
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1-Bromo-4-(3-bromopropyl)benzene
0 ImagesCat. No.: HY-W105760CAS No.: 90562-10-0
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tert-Butyl 4-(hydroxymethyl)benzylcarbamate
0 ImagesCat. No.: HY-W046402CAS No.: 123986-64-1
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Boc-piperidin-C-COOH
0 ImagesCat. No.: HY-W001860CAS No.: 157688-46-5
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1-Bromo-3-(3-bromopropoxy)propane
0 ImagesCat. No.: HY-W251782CAS No.: 58929-72-9
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tert-Butyl 5-hydroxypentanoate
0 ImagesCat. No.: HY-W564966CAS No.: 91420-49-4
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3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride
![3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride](https://file.medchemexpress.com/product_pic/hy-w000162.gif "Click to View 3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride Product Detail")
0 ImagesCat. No.: HY-W000162CAS No.: 1172097-47-0
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TBS-PEG2-OH
0 ImagesCat. No.: HY-W044212CAS No.: 131326-39-1
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1,18-Dibromooctadecane
0 ImagesCat. No.: HY-W583741CAS No.: 31772-06-2
