PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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3-(4-Bromophenyl)propan-1-ol
0 ImagesCat. No.: HY-32169CAS No.: 25574-11-2
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3-((tert-Butoxycarbonyl)amino)propyl 4-methylbenzenesulfonate
0 ImagesCat. No.: HY-W570686CAS No.: 80909-96-2
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tert-Butyl hept-6-yn-1-ylcarbamate
0 ImagesCat. No.: HY-W247245CAS No.: 1192373-48-0
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3-Boc-3,9-Diazaspiro[5.5]undecane hydrochloride
![3-Boc-3,9-Diazaspiro[5.5]undecane hydrochloride](https://file.medchemexpress.com/product_pic/hy-30533.gif "Click to View 3-Boc-3,9-Diazaspiro[5.5]undecane hydrochloride Product Detail")
0 ImagesCat. No.: HY-30533CAS No.: 236406-47-6
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2-(3-Chloropropyl)-1,3-dioxolane
0 ImagesCat. No.: HY-W017415CAS No.: 16686-11-6
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10-Bromodecanoic acid
0 ImagesSynonyms: Decanoic acid, 10-bromo-
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4-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylic acid
0 ImagesCat. No.: HY-W041240CAS No.: 130309-46-5
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tert-Butyl (3-(3-aminopropoxy)propyl)carbamate
0 ImagesCat. No.: HY-W575526CAS No.: 848419-01-2
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5-Bromopentan-1-amine hydrobromide
0 ImagesCat. No.: HY-77482CAS No.: 51874-27-2
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Hept-6-yn-1-amine
0 ImagesCat. No.: HY-W072790CAS No.: 14502-42-2Synonyms: 7-Amino-1-heptyne
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Boc-C17-COOH
0 ImagesCat. No.: HY-W092036CAS No.: 1643852-37-2
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Methyl 4-piperazin-1-ylbenzoate
0 ImagesCat. No.: HY-W079028CAS No.: 163210-97-7
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tert-Butyl 11-bromoundecanoate
0 ImagesCat. No.: HY-W130363CAS No.: 85216-74-6
![tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w120561.gif "Click to View tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate Product Detail")
