PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Tert-butyl 4-(2-bromoethyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W046489CAS No.: 169457-73-2
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MeOAc-PEG2-acid
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3-(benzyloxy)propanoic acid
0 ImagesCat. No.: HY-W046360CAS No.: 27912-85-2
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tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W046163CAS No.: 373608-48-1
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Boc-2-methylamino-ethylcarbamate hydrochloride
0 ImagesCat. No.: HY-76236CAS No.: 202207-79-2
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1,14-Dibromotetradecane
0 ImagesCat. No.: HY-W109310CAS No.: 37688-96-3
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Boc-Pip-cyclohexane-OH
0 ImagesCat. No.: HY-W114070CAS No.: 918644-73-2
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2-(3-Bromopropoxy)tetrahydro-2H-pyran
0 ImagesCat. No.: HY-W008007CAS No.: 33821-94-2
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4-((tert-Butyldimethylsilyl)oxy)butan-1-amine
0 ImagesCat. No.: HY-W440597CAS No.: 245660-15-5
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3-(4-Iodophenyl)propanoic acid
0 ImagesCat. No.: HY-W104869CAS No.: 1643-29-4
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Methyl 2-(4-(aminomethyl)phenyl)acetate hydrochloride
0 ImagesCat. No.: HY-W077308CAS No.: 99075-25-9
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Br-CO-piperazine-Boc
0 ImagesCat. No.: HY-W133880CAS No.: 112257-12-2
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1,16-Dibromohexadecane
0 ImagesCat. No.: HY-W131244CAS No.: 45223-18-5
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Boc-azetidine-cyclohexanamine
0 ImagesCat. No.: HY-W050183CAS No.: 1408075-19-3
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12-Bromododecan-1-ol
0 ImagesSynonyms: 12-Bromododecanol
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tert-Butyl ((4-oxocyclohexyl)methyl)carbamate
0 ImagesCat. No.: HY-W024496CAS No.: 809273-70-9
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tert-Butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate
![tert-Butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056572.gif "Click to View tert-Butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056572CAS No.: 1225276-07-2
