PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
![4-Hydroxybicyclo[2.2.2]octane-1-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-35450.gif "Click to View 4-Hydroxybicyclo[2.2.2]octane-1-carboxylic acid Product Detail")
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tert-Butyl 4-(4-hydroxybutyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-33021CAS No.: 142355-83-7
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Z-Glycinol
0 ImagesSynonyms: N-Z-ethanolamine
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tert-Butyl (E)-4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W044394CAS No.: 1160924-51-5
![Methyl 6-oxospiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w057067.gif "Click to View Methyl 6-oxospiro[3.3]heptane-2-carboxylate Product Detail")
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11-Aminoundecanoic acid
0 ImagesCat. No.: HY-W014831CAS No.: 2432-99-7
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m-PEG6-CH2CH2COOH
0 ImagesCat. No.: HY-W040239CAS No.: 874208-91-0
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NH-bis(PEG4-acid)
0 ImagesCat. No.: HY-140516CAS No.: 2055041-59-1
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Bromo-PEG1-CH2COOH
0 ImagesCat. No.: HY-130163CAS No.: 1135131-50-8
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Tetrazine-Ph-NHS ester
0 ImagesCat. No.: HY-126908CAS No.: 1616668-55-3Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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AEEA-AEEA
0 ImagesAEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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NH2-PEG3-C6-Cl
0 ImagesCat. No.: HY-138469CAS No.: 1261350-60-0
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Boc-PEG4-C2-NHS ester
0 ImagesCat. No.: HY-141122CAS No.: 1835759-75-5
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DBCO-PEG5-DBCO
0 ImagesCat. No.: HY-140302CAS No.: 2363130-04-3
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Azido-PEG5-CH2CO2-NHS
0 ImagesCat. No.: HY-140766CAS No.: 2144777-77-3Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
