PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Bis-PEG5-acid
0 ImagesSynonyms: PROTAC Linker 36
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D-Proline, 4-hydroxy-, methyl ester hydrochloride
0 ImagesCat. No.: HY-76105CAS No.: 114676-59-4D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
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Boc-NH-PEG7-propargyl
0 ImagesCat. No.: HY-140882CAS No.: 2112737-90-1
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Bromo-PEG6-azide
0 ImagesCat. No.: HY-140823CAS No.: 2062663-64-1Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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FmocNH-PEG2-CH2CONH-PEG2-CH2COOH
0 ImagesCat. No.: HY-W109760CAS No.: 560088-89-3FmocNH-PEG2-CH2CONH-PEG2-CH2COOH is an optimized, extended PEG-like linker[1].
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Suberic acid-d4
0 ImagesSynonyms: Octanedioic acid-d4Suberic acid-d4 (Octanedioic acid-d4) is the deuterated-labeled Suberic acid (HY-W015300). Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
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Azido-PEG24-alcohol
0 ImagesAzido-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Hydroxy-PEG4-C2-methyl ester
0 ImagesCat. No.: HY-141242CAS No.: 2228857-35-8
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Azide-PEG8-alcohol
0 ImagesCat. No.: HY-140799CAS No.: 352439-36-2Azide-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG8-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl 11-aminoundecanoate
0 Imagestert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Azido-PEG7-acid
0 ImagesCat. No.: HY-132078Purity: 99.95%Azido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG10-amine
0 Imagesm-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Bromoacetamido-PEG3-C2-Boc
0 ImagesCat. No.: HY-141388CAS No.: 1807537-33-2
