PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
NH2-PEG8-OH
0 ImagesCat. No.: HY-130200CAS No.: 352439-37-3
-
m-PEG2-acid
0 ImagesCat. No.: HY-130231CAS No.: 149577-05-9
-
Hydroxy-PEG4-CH2-Boc
0 ImagesCat. No.: HY-42617CAS No.: 169751-72-8
-
CH2COOH-PEG3-CH2COOH
0 ImagesCat. No.: HY-122696CAS No.: 32775-08-9
-
(4S)-4-Hydroxy-D-proline methyl ester hydrochloride
0 Images(4S)-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (4S)-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
-
Bis-propargyl-PEG4
0 ImagesCat. No.: HY-120397CAS No.: 159428-42-9Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
Bis-Tos-PEG4
0 ImagesSynonyms: PROTAC Linker 16
-
TBDMS-PEG4-OH
0 ImagesCat. No.: HY-W042579CAS No.: 134179-40-1
-
Azido-PEG1-azide
0 ImagesAzido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Bromo-PEG6-bromide
0 ImagesCat. No.: HY-135049CAS No.: 72713-23-6
-
N-(Azido-PEG3)-N-bis(PEG4-acid)
0 ImagesN-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Fmoc-NH-PEG5-CH2COOH
0 ImagesCat. No.: HY-133062CAS No.: 635287-26-2Fmoc-NH-PEG5-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
-
Propargyl-PEG4-CH2COOH
0 ImagesCat. No.: HY-140023CAS No.: 1429934-37-1
-
Amino-PEG10-amine
0 ImagesCat. No.: HY-W040270CAS No.: 928292-69-7
