DOTA-PEG5-amine
Based on 1 Customer Validation
DOTA-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 98.0%
- Formula: C28H54N6O12
- Molecular Weight:666.76
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 666.76
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Formula C28H54N6O12
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Color White to off-white
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SMILES
O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(NCCOCCOCCOCCOCCOCCN)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (74.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.4998 mL | 7.4990 mL | 14.9979 mL | 37.4948 mL |
| 5 mM | 0.3000 mL | 1.4998 mL | 2.9996 mL | 7.4990 mL | |
| 10 mM | 0.1500 mL | 0.7499 mL | 1.4998 mL | 3.7495 mL | |
| 15 mM | 0.1000 mL | 0.4999 mL | 0.9999 mL | 2.4997 mL | |
| 20 mM | 0.0750 mL | 0.3749 mL | 0.7499 mL | 1.8747 mL | |
| 25 mM | 0.0600 mL | 0.3000 mL | 0.5999 mL | 1.4998 mL | |
| 30 mM | 0.0500 mL | 0.2500 mL | 0.4999 mL | 1.2498 mL | |
| 40 mM | 0.0375 mL | 0.1875 mL | 0.3749 mL | 0.9374 mL | |
| 50 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7499 mL | |
| 60 mM | 0.0250 mL | 0.1250 mL | 0.2500 mL | 0.6249 mL |
DOTA-PEG5-amine Related Classifications
HY-140008 Related Classifications
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