Biotin-PEG3-propionic hydrazide

Name: Biotin-PEG3-propionic hydrazide
Brand: MedChemExpress
SKU: HY-130560
Rating: 4.5 (1 reviews)

Cat. No.: HY-130560 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Biotin-PEG3-propionic hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

For research use only. We do not sell to patients.

Biotin-PEG3-propionic hydrazide Chemical Structure

CAS No. : 1381861-94-4

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Description

Biotin-PEG3-propionic hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.58

Formula

C₁₉H₃₅N₅O₆S

CAS No.

1381861-94-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCOCCC(NN)=O)CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (216.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1665 mL	10.8324 mL	21.6647 mL
5 mM	0.4333 mL	2.1665 mL	4.3329 mL
10 mM	0.2166 mL	1.0832 mL	2.1665 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.0%

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Data Sheet (239 KB) SDS (393 KB)

COA (243 KB) HNMR (286 KB) MS (69 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1665 mL	10.8324 mL	21.6647 mL	54.1618 mL
	5 mM	0.4333 mL	2.1665 mL	4.3329 mL	10.8324 mL
	10 mM	0.2166 mL	1.0832 mL	2.1665 mL	5.4162 mL
	15 mM	0.1444 mL	0.7222 mL	1.4443 mL	3.6108 mL
	20 mM	0.1083 mL	0.5416 mL	1.0832 mL	2.7081 mL
	25 mM	0.0867 mL	0.4333 mL	0.8666 mL	2.1665 mL
	30 mM	0.0722 mL	0.3611 mL	0.7222 mL	1.8054 mL
	40 mM	0.0542 mL	0.2708 mL	0.5416 mL	1.3540 mL
	50 mM	0.0433 mL	0.2166 mL	0.4333 mL	1.0832 mL
	60 mM	0.0361 mL	0.1805 mL	0.3611 mL	0.9027 mL
	80 mM	0.0271 mL	0.1354 mL	0.2708 mL	0.6770 mL
	100 mM	0.0217 mL	0.1083 mL	0.2166 mL	0.5416 mL