2. PROTAC
  3. PROTAC Linkers
  4. NH2-PEG3-C6-Cl

NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-PEG3-C6-Cl Chemical Structure

NH2-PEG3-C6-Cl Chemical Structure

CAS No. : 1261350-60-0

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25 mg USD 155 In-stock
50 mg USD 250 In-stock
100 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

NH2-PEG3-C6-Cl Related Antibodies

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Description

NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-PEG3-C6-Cl Related Antibodies
Molecular Weight

267.79

Formula

C12H26ClNO3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

ClCCCCCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (373.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7343 mL 18.6713 mL 37.3427 mL
5 mM 0.7469 mL 3.7343 mL 7.4685 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7343 mL 18.6713 mL 37.3427 mL 93.3567 mL
5 mM 0.7469 mL 3.7343 mL 7.4685 mL 18.6713 mL
10 mM 0.3734 mL 1.8671 mL 3.7343 mL 9.3357 mL
15 mM 0.2490 mL 1.2448 mL 2.4895 mL 6.2238 mL
20 mM 0.1867 mL 0.9336 mL 1.8671 mL 4.6678 mL
25 mM 0.1494 mL 0.7469 mL 1.4937 mL 3.7343 mL
30 mM 0.1245 mL 0.6224 mL 1.2448 mL 3.1119 mL
40 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3339 mL
50 mM 0.0747 mL 0.3734 mL 0.7469 mL 1.8671 mL
60 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5559 mL
80 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1670 mL
100 mM 0.0373 mL 0.1867 mL 0.3734 mL 0.9336 mL
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NH2-PEG3-C6-Cl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG3-C6-Cl1261350-60-0PROTAC LinkersInhibitorinhibitorinhibit

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