1. PROTAC
  2. PROTAC Linkers
  3. Aminooxy-PEG5-azide

Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Aminooxy-PEG5-azide Chemical Structure

Aminooxy-PEG5-azide Chemical Structure

CAS No. : 1919045-02-5

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25 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

322.36

Formula

C12H26N4O6

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

NOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (310.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1021 mL 15.5106 mL 31.0212 mL
5 mM 0.6204 mL 3.1021 mL 6.2042 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1021 mL 15.5106 mL 31.0212 mL 77.5530 mL
5 mM 0.6204 mL 3.1021 mL 6.2042 mL 15.5106 mL
10 mM 0.3102 mL 1.5511 mL 3.1021 mL 7.7553 mL
15 mM 0.2068 mL 1.0340 mL 2.0681 mL 5.1702 mL
20 mM 0.1551 mL 0.7755 mL 1.5511 mL 3.8777 mL
25 mM 0.1241 mL 0.6204 mL 1.2408 mL 3.1021 mL
30 mM 0.1034 mL 0.5170 mL 1.0340 mL 2.5851 mL
40 mM 0.0776 mL 0.3878 mL 0.7755 mL 1.9388 mL
50 mM 0.0620 mL 0.3102 mL 0.6204 mL 1.5511 mL
60 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2926 mL
80 mM 0.0388 mL 0.1939 mL 0.3878 mL 0.9694 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7755 mL
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Aminooxy-PEG5-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aminooxy-PEG5-azide
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