2. Signaling Pathways
  3. Immunology/Inflammation
  4. Cyclophilin

Cyclophilin

Cyclophilins are enzymes that accelerate the rotation of the peptide bond in front of a proline residue. Cyclophilins are involved in a wide variety of cellular processes such as folding, posttranslational modifications and transport of proteins, assembly of essential cellular protein complexes, and cell signaling. Cyclophilins have been identified in a range of organisms, including mammals, plants, insects, fungi, and bacteria.

The prototypic cyclophilin A (CypA) is the most abundant member of the cyclophilin family in human tissue and the major player in the cellular PPIase activity. CypA as a host cell protein interacts with viral proteins and can thus promote or inhibit viral replication and infection of a variety of RNA viruses, most prominently HIV‐1 and HCV.

Cyclophilin Isoform Specific Products:

Cyclophilin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173009
    PROTAC CG167
    		Degrader
    PROTAC CG167 is a selective and potent CypA PROTAC degrader. PROTAC CG167 degrades CypA in a dose-dependent manner (Jurkat: DC50: 123 nM). PROTAC CG167 can inhibit HIV-1 and HCV and exhibits antiviral activity. (Pink: CypA Ligand (HY-170997); Black: Linker (HY-W123015); Blue: E3 Ligase Ligand (HY-112078))
    PROTAC CG167
  • HY-173013
    TWH106
    		Inhibitor
    TWH106 is an inhibitor for Cyclophilin (Cyp) that exhibits good affinity to CypA and CypB with KD of 53 nM and 139 nM. TWH106 inhibits the replication of HIV and HCV, exhibiting antiviral activity.
    TWH106
  • HY-107635R
    TMN355 (Standard)
    		Inhibitor
    TMN355 (Standard) is the analytical standard of TMN355 (HY-107635). This product is intended for research and analytical applications. TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytoKine secretion. TMN355 is used for atherosclerosis.
    TMN355 (Standard)
  • HY-P1355
    Cyclosporin A-Derivative 1
    Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    Cyclosporin A-Derivative 1
Cyclophilin Isoform Comparison

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