Cyclophilin
Cyclophilins are enzymes that accelerate the rotation of the peptide bond in front of a proline residue. Cyclophilins are involved in a wide variety of cellular processes such as folding, posttranslational modifications and transport of proteins, assembly of essential cellular protein complexes, and cell signaling. Cyclophilins have been identified in a range of organisms, including mammals, plants, insects, fungi, and bacteria.
The prototypic cyclophilin A (CypA) is the most abundant member of the cyclophilin family in human tissue and the major player in the cellular PPIase activity. CypA as a host cell protein interacts with viral proteins and can thus promote or inhibit viral replication and infection of a variety of RNA viruses, most prominently HIV‐1 and HCV.
Cyclophilin Isoform Specific Products
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Cyclophilin Related Products (47)
Related Products (47)
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Cyclophilin Isoform Comparison
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ZX-J-19j
0 ImagesCat. No.: HY-155172CAS No.: 1352576-02-3ZX-J-19j (Compound ZX-J-19j) is a cyclophilin J inhibitor. ZX-J-19j showes potent antitumor activity.
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M9-5 sodium
0 ImagesCat. No.: HY-164186M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.
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NIM258
0 ImagesCat. No.: HY-128924CAS No.: 1589093-01-5NIM258 is a potent nonimmunosuppressive cyclophilin inhibitor (cyclophilin A Kd = 1.2 nM) with anti-HCV activity (EC50 = 40 nM). NIM258 can be used for HCV infection research.
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TMN355 (Standard)
0 ImagesCat. No.: HY-107635RCAS No.: 1186372-20-2TMN355 (Standard) is the analytical standard of TMN355 (HY-107635). This product is intended for research and analytical applications. TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytoKine secretion. TMN355 is used for atherosclerosis.
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Cyclosporin A-Derivative 1
0 ImagesCat. No.: HY-P1355CAS No.: 1487360-85-9Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cyclosporin A-d3
0 ImagesCat. No.: HY-B0579S1CAS No.: 222295-76-3Synonyms: Cyclosporine A-d3; Ciclosporin A-d3; CsA-d3Cyclosporin A-d3 (Cyclosporine A-d3) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.
