2. Signaling Pathways
  3. Immunology/Inflammation
  4. Cyclophilin
  5. Cyclophilin Ligand

Cyclophilin Ligand

Cyclophilin Isoform Comparison

Cyclophilin Ligands (2):

Cat. No. Product Name Effect Purity
  • HY-186087
    RM-046
    		Ligand
    RM-046 is an orally active, selective ternary complex inhibitor of KRASQ61H (active form). RM-046 forms a ternary complex with cyclophilin A, binds to active KRASQ61H in a non-covalent manner, blocks effector binding via steric hindrance and inhibits downstream signal transduction. RM-046 inhibits ERK phosphorylation and cancer cell proliferation, and induces sustained RAS pathway signal inhibition, anti-tumor activity and tumor regression in preclinical xenograft models. RM-046 can be used for the research of KRASQ61H mutant cancers.
  • HY-170997
    CypA ligand-1
    		Ligand
    CypA ligand-1 is the ligand for CypA that can be used as target protein ligand for synthesis of PROTAC degrader PROTAC CG167 (HY-173009).