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TMN355 

Cat. No.: HY-107635
Handling Instructions

TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis.

For research use only. We do not sell to patients.

TMN355 Chemical Structure

TMN355 Chemical Structure

CAS No. : 1186372-20-2

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Description

TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].

IC50 & Target

cyclophilin A[1]

In Vitro

TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1].

Western Blot Analysis[1]

Cell Line: THP cell lines
Concentration: 0.5, 1, 2.5, 5 and 10 μM
Incubation Time: 3, 6 and 9 hours
Result: Resulted in 75.9% reduction of cyclophilin A protein expression.
Molecular Weight

380.80

Formula

C₂₁H₁₄ClFN₂O₂

CAS No.

1186372-20-2

SMILES

O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TMN355
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