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TMN355 

Cat. No.: HY-107635 Purity: 99.57%
Handling Instructions

TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis.

For research use only. We do not sell to patients.

TMN355 Chemical Structure

TMN355 Chemical Structure

CAS No. : 1186372-20-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].

IC50 & Target

cyclophilin A[1]

In Vitro

TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: THP cell lines
Concentration: 0.5, 1, 2.5, 5 and 10 μM
Incubation Time: 3, 6 and 9 hours
Result: Resulted in 75.9% reduction of cyclophilin A protein expression.
Molecular Weight

380.80

Formula

C₂₁H₁₄ClFN₂O₂

CAS No.
SMILES

O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (82.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6261 mL 13.1303 mL 26.2605 mL
5 mM 0.5252 mL 2.6261 mL 5.2521 mL
10 mM 0.2626 mL 1.3130 mL 2.6261 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.57%

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Keywords:

TMN355TMN 355TMN-355OthersInhibitorinhibitorinhibit

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TMN355
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HY-107635
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