Cyclophilin
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Cyclophilin Related Products (21)
Related Products (21)
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NIM811
0 ImagesSynonyms: (Melle-4)cyclosporin; SDZ NIM811NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) .
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Alisporivir
0 ImagesSynonyms: Debio-025; DEB-025Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
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Cyclosporin
0 ImagesCyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes.
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Pan-RAS-IN-2
0 ImagesPan-rasin-2 (compound 6A) is an orally active molecular glues that targets RAS. Pan-RAS-IN-2 inhibits pERK (IC50 in AsPC-1 cells: 0.3 nM). Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor (such as colorectal cancer, pancreatic cancer) effects.
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RJS308 TFA
0 ImagesCat. No.: HY-173011APurity: 98.36%RJS308 TFA is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 TFA induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 TFA exhibits anti-HIV-1 and anti-HCV activities. RJS308 TFA can be used in studies related to viral infections.
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RN-0001
0 ImagesCat. No.: HY-P11489CAS No.: 252731-57-0RN-0001 is a cyclophilin (Cyp) inhibitor with Ki values of 4.1 nM and 12.0 nM against CypA and CypD, respectively, and an EC50 of 916 nM for CypD. RN-0001 binds directly to CypD, inhibits the peptidyl-prolyl cis-trans isomerase activities of CypD and CypA, and prevents CypD-dependent mitochondrial permeability transition pore opening. RN-0001 improves mitochondrial function, reduces ROS production, inhibits the expression of lipogenic markers, blocks the nuclear translocation of NF-κB p65, and decreases the release of activated caspase-3 and cytochrome c. RN-0001 can be used in the research of alcohol-associated liver disease.
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ZX-J-19L
0 ImagesCat. No.: HY-182397CAS No.: 1346754-06-0
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Isocyclosporin A
0 ImagesIsocyclosporin A is a degradation product of the immunosuppressant Cyclosporin A.
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Cyclosporin A-Derivative 1 Free base
0 ImagesCyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cyclosporin A-Derivative 2
0 ImagesCat. No.: HY-P1354CAS No.: 156047-45-9Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cyclosporin A-KLH
0 ImagesCat. No.: HY-NP194BCyclosporin A-KLH is a conjugate of Cyclosporin A (HY-B0579) and KLH. Cyclosporin A is an immunosuppressant which binds to the cyclophilin .
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ASP5286
0 ImagesCat. No.: HY-P3351CAS No.: 935735-70-9ASP5286 is a novel non-immunosuppressive cyclophilin inhibitor for the research of HCV.
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SMCypI C31
0 ImagesCat. No.: HY-125182CAS No.: 2649904-85-6SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction.
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CypD-IN-29
0 ImagesCat. No.: HY-136804CAS No.: 1115335-95-9CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP).
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Pan-RAS-IN-5
0 ImagesCat. No.: HY-162536Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects.
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Cyclosporin A-OVA
0 ImagesCat. No.: HY-NP194ACyclosporin A-OVA is a conjugate of Cyclosporin A (HY-B0579) and OVA. Cyclosporin A is an immunosuppressant which binds to the cyclophilin .
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ZX-J-19j
0 ImagesCat. No.: HY-155172CAS No.: 1352576-02-3ZX-J-19j (Compound ZX-J-19j) is a cyclophilin J inhibitor. ZX-J-19j showes potent antitumor activity.
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M9-5 sodium
0 ImagesCat. No.: HY-164186M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.
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TMN355 (Standard)
0 ImagesCat. No.: HY-107635RCAS No.: 1186372-20-2
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