3034673-92-9
Chemical Structure
Pan-RAS-IN-2
- CAS No.: 3034673-92-9
- Formula:C46H60N8O5S
- Molecular Weight:837.08
InChIKey: DPKDQKDHUDKBNH-OSNNMTMHSA-N
SMILES: O=C1OCC(C)(CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC(N4CCN(C)CC4)=C3)N(CC)C5=CC=C(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8N[C@H]1C9CC8C9)=O)=N6)C=C25)C
Biological Activity: Pan-rasin-2 (compound 6A) is an orally active molecular glues that targets RAS. Pan-RAS-IN-2 inhibits pERK (IC50 in AsPC-1 cells: 0.3 nM). Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor (such as colorectal cancer, pancreatic cancer) effects[1].
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Pan-RAS-IN-2 | 99.74% | Pan-rasin-2 (compound 6A) is an orally active molecular glues that targets RAS. Pan-RAS-IN-2 inhibits pERK (IC50 in AsPC-1 cells: 0.3 nM). Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor (such as colorectal cancer, pancreatic cancer) effects. | ||||||||||||||||||||
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Keywords
