1115335-95-9
Chemical Structure
CypD-IN-29
- CAS No.: 1115335-95-9
- Formula:C26H20FN5O2S
- Molecular Weight:485.53
IUPAC Name: 3-(2-((2-((2-cyanophenyl)amino)-2-oxoethyl)thio)-1H-imidazol-1-yl)-N-(4-fluorobenzyl)benzamide
InChIKey: WAPJUYVZASTWRM-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(F)C=C1)C2=CC=CC(N3C=CN=C3SCC(NC4=CC=CC=C4C#N)=O)=C2
Biological Activity: CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP).
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CypD-IN-29 | CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP). | |||||||||||||||||||||
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Keywords
