Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Related Products (4010)
Related Products (4010)
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1-(3-Chloro-4-fluorophenyl)piperazine hydrochloride
0 ImagesCat. No.: HY-W351428CAS No.: 95884-48-31-(3-Chloro-4-fluorophenyl)piperazine hydrochloride is a piperazine.
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Thiazolidinone-Derivatives-1
0 ImagesThiazolidinone-Derivatives-1 is an antiulcer agent which inhibits the secretion of gastric acid.
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Antifungal agent 141
0 ImagesCat. No.: HY-179704Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis.
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Antiproliferative agent-75
0 ImagesCat. No.: HY-181473CAS No.: 3102226-11-6Antiproliferative agent-75, Pyrrole (HY-Y0807) derivative, is an antiproliferative agent with an IC50 value of 0.06 μM against Myc-driven human B-cells. Antiproliferative agent-75 can be used for the development of pyrrole-based Myc inhibitor.
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trans-2,3,4-Trimethoxycinnamic acid
0 ImagesCat. No.: HY-W008770CAS No.: 33130-03-9trans-2,3,4-Trimethoxycinnamic acid is a Phenylpropanoids product that can be isolated from the barks of Chinese cinnamon.
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3',4'-Trimethylene-α-pyrrolidinobutiophenone hydrochloride
0 ImagesCat. No.: HY-168402CAS No.: 2749618-47-93',4'-Trimethylene-α-pyrrolidinobutiophenone hydrochloride is classified as a drug derivative.
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Dotarizine
0 ImagesCat. No.: HY-137162CAS No.: 84625-59-2Dotarizine is a novel Piperazine (HY-B0912) derivative and antimigraine agent. Dotarizine exhibits Ca2+ channel blocking properties. Dotarizine decreases the release of lactate dehydrogenase. Dotarizine shows 5-HT receptor blocking effect.
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Hericenone A
0 ImagesCat. No.: HY-N15388CAS No.: 126654-52-2
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Rehmannioside B
0 ImagesCat. No.: HY-N10694CAS No.: 81720-06-1Rehmannioside B is an iridoid compound that can be found in the root tuber of Rehmannia glutinosa Libosch, stem bark and root of Feretia apodanthera.
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Jaconine N-oxide
0 ImagesCat. No.: HY-N20655CAS No.: 1148039-75-1Jaconine N-oxide is a dechlorination product of Jacobine N-oxide (HY-N9511).
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4-((Carboxymethyl)amino)benzoic acid
0 ImagesCat. No.: HY-W614122CAS No.: 5698-54-4Synonyms: 4-COOH-Hippuric acid; 4-[(Carboxymethyl)amino]benzoic acid4-((Carboxymethyl)amino)benzoic acid (4-COOH-Hippuric acid) is a derivative of 4-Aminobenzoic acidchorismate (PABA) (HY-B1008). 4-((Carboxymethyl)amino)benzoic acid is a competitive inhibitor of 4-Amino-4-deoxychorismate synthase.
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Piperidione
0 ImagesCat. No.: HY-W181871CAS No.: 77-03-2Piperidione is a cough agent.
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3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin
0 ImagesCat. No.: HY-W145571CAS No.: 189307-64-0Synonyms: 3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin is a derivative of γ-Cyclodextrin (HY-W040040).
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Dihydromunduletone (Standard)
0 ImagesCat. No.: HY-101483RCAS No.: 674786-20-0Dihydromunduletone (Standard) is the analytical standard of Dihydromunduletone (HY-101483). This product is intended for research and analytical applications. Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs.
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25G-NBOMe hydrochloride
0 ImagesCat. No.: HY-135448CAS No.: 1797132-54-725G-NBOMe hydrochloride is a derivative of 2,5-phenethylamines, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.
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N,N-dimethyl-N'-p-tolylsulfamide
0 ImagesCat. No.: HY-W286414CAS No.: 66840-71-9Synonyms: DMSTN,N-dimethyl-N'-p-tolylsulfamide (DMST) is a hydrolysis product of Tolylfluanid (HY-W774955). The photodegradation rate of N,N-dimethyl-N'-p-tolylsulfamide in coastal seawater is higher than that in seawater or deionized water.
