Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4010)
Related Products (4010)
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Norjuziphine
0 ImagesCat. No.: HY-N10337CAS No.: 74119-87-2Synonyms: (-)-NorjuziphineNorjuziphine ((-)-Norjuziphine) is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC50=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases.
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Bosutinib N-Oxide
0 ImagesCat. No.: HY-W770773CAS No.: 2468737-96-2Bosutinib N-Oxide (Compound 80) is a quinoline-type heterocyclic compound. Bosutinib N-Oxide shows anti-proliferative activity and can be used for research of leukemia.
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Zibrofusidic acid
0 ImagesCat. No.: HY-156921CAS No.: 827603-95-2Synonyms: 24-Bromofusidic acid; TD-1414Zibrofusidic acid (24-Bromofusidic acid; TD-1414) is a brominated derivative of Fusidic acid (HY-B1350). Zibrofusidic acid can be combined within the hydrophobic groove formed by the transmembrane helix 1 (TM1) and the transmembrane helix 2 (TM2) of the AcrB protein. Zibrofusidic acid can be used for the research of multidrug efflux pump.
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6'Nicotinate Ac4ManNAz
0 ImagesCat. No.: HY-177738CAS No.: 2102591-12-66'Nicotinate Ac4ManNAz (Compound 2) is a brain-penetrant carbohydrate-neuroactive heteromer conjugating Ac4ManNAz (HY-W728531) and Nicotinic acid (HY-B0143). 6'Nicotinate Ac4ManNAz can be used for the development of glycosylation-regulating agents or diagnostic probes that cross the BBB.
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4-Trehalosamine
0 ImagesCat. No.: HY-N15182CAS No.: 51855-99-34-Trehalosamine is a derivative of trehalose with weak antibacterial activity. 4-Trehalosamine shows no toxic effects when injected intravenously into mice at a dose of 625 mg/kg.
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N-Propyl buphedrone hydrochloride
0 ImagesCat. No.: HY-W719011CAS No.: 18267-91-9N-Propyl buphedrone hydrochloride is a drug derivative.
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(±)-Threo-Isopropylphenidate hydrochloride
0 ImagesCat. No.: HY-138873CAS No.: 1262795-94-7(±)-Threo-Isopropylphenidate hydrochloride is structurally categorized as a phenethylamine.
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N-Mitrososarcosine
0 ImagesCat. No.: HY-W188178CAS No.: 13256-22-9
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Solanacol
0 ImagesCat. No.: HY-N15133CAS No.: 953389-72-5Synonyms: (-)-SolanacolSolanacol ((-)-Solanacol) is a strigolactone germination stimulant that can be isolated from tobacco (Nicotiana tabacum L.). Solanacol stimulates the germination of root parasitic weed seeds.
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3-Et-3TC
0 ImagesCat. No.: HY-176994CAS No.: 1995864-98-63-Et-3TC (Page 87, Compound 3b) is a structurally modified derivative of Lamivudine (HY-B0250). 3-Et-3TC can inhibit the activation of the NLRP3 inflammasome and can be used for the study of retinal degenerative diseases.
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Copper(II) ionophore I
0 ImagesCat. No.: HY-49457CAS No.: 125769-67-7Copper(II) ionophore I is a neutral Cu+ ionophore.
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Antibacterial agent 345
0 ImagesCat. No.: HY-183712Antibacterial agent 345 is a Ciprofloxacin (HY-B0356)-lipophilic derivative and is an antibacterial agent. Antibacterial agent 345 inhibits DNA gyrase and inhibits bacterial DNA replication and transcription. Antibacterial agent 345 inhibits bacterial biofilm formation. Antibacterial agent 345 can be used for the research of bacterial infections, such as Pseudomonas aeruginosa infection.
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Bisacurone B
0 ImagesCat. No.: HY-N13030CAS No.: 127214-85-1Bisacurone B is a natural sesquiterpene.
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2-CEC hydrochloride
0 ImagesCat. No.: HY-W715084CAS No.: 879660-23-82-CEC hydrochloride is structurally categorized as a drug derivative.
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3-(Methylthio)propyl acetate
0 ImagesCat. No.: HY-N7818CAS No.: 16630-55-03-(Methylthio)propyl acetate is a heavy volatile sulfur compound with mushroom, onion, garlic odour. 3-(Methylthio)propyl acetate can be found in Vinhos Verdes wines. 3-(Methylthio)propyl acetate occurs in high content in Trajadura wines and low content in Azal Branco wines.
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BASF 43915
0 ImagesCat. No.: HY-19597CAS No.: 91587-01-8Synonyms: ORF 18704; RWJ 18704BASF 43915 (Pelretin) is a Phenyl analog.
