518-20-7
518-20-7
Chemical Structure
Pyranocoumarin
- CAS No.: 518-20-7
- Formula:C20H18O4
- Molecular Weight:322.36
IUPAC Name: 2-methoxy-2-methyl-4-phenyl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromen-5-one
InChIKey: ZGFASEKBKWVCGP-UHFFFAOYSA-N
SMILES: O=C1OC=2C=CC=CC2C=3OC(OC)(C)CC(C=4C=CC=CC4)C13
Biological Activity: Pyranocoumarin (Compound 13) is a heterocyclic scaffold (coumarin + pyran ring fusion). Pyranocoumarin inhibits the S-warfarin hydroxylation catalyzed by CYP2C9[1][2].
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Pyranocoumarin | Pyranocoumarin (Compound 13) is a heterocyclic scaffold (coumarin + pyran ring fusion). Pyranocoumarin inhibits the S-warfarin hydroxylation catalyzed by CYP2C9. | |||||||||||||||||||||
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References
- [1]. Zhou SF, et al. Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. [Content Brief]
- [2]. Maurer HH, et al. Detection of 4-hydroxycoumarin anticoagulants and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation. J Chromatogr B Biomed Sci Appl. 1998;714(2):181-195. [Content Brief]
Keywords
