Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4037)
Related Products (4037)
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Derpanicate
0 ImagesCat. No.: HY-105020CAS No.: 99518-29-3Derpanicate is a Nicotinic acid (HY-B0143) ester. Derpanicate has antihypercholesterolaemic and/or vasodilating effects.
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Cronupapin methyl ester
0 ImagesCat. No.: HY-N21525CAS No.: 1454585-35-3Cronupapin methyl ester is a 2-benzylmalate benzyl ester glucoside found in the tubers of Cremastra appendiculata with IC50 > 50 μM against cancer cells.
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AfaPhos1
0 ImagesCat. No.: HY-176938AfaPhos1 is a new, Afatinib (HY-10261)-based EGFR PhosTAC. AfaPhos1 induces EGFR dephosphorylation at both pY1068 and pY845. AfaPhos1 induces Apoptosis. AfaPhos1 has anticancer activity against non-small cell lung cancer.
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Valproic acid hydroxamate
0 ImagesCat. No.: HY-133160CAS No.: 106132-78-9Synonyms: VPA-HAValproic acid hydroxamate (VPA-HA) has shown anticonvulsant activity in a mouse neural tube defect model, without any teratogenic effects.
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S-Ethylglutathione
0 ImagesCat. No.: HY-131390CAS No.: 24425-52-3S-Ethylglutathione is a biochemical.
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1β-Hydroxy-8α-methoxyeremophila-7(11),9-dien-12,8β-olide
0 ImagesCat. No.: HY-N17157CAS No.: 849700-45-41β-Hydroxy-8α-methoxyeremophila-7(11),9-dien-12,8β-olide is a natural sesquiterpene.
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1-Oxohederagenin
0 ImagesCat. No.: HY-N13805CAS No.: 618390-67-31-Oxohederagenin is a natural triterpene.
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Quassidine B
0 ImagesCat. No.: HY-N17010CAS No.: 1207862-37-0Synonyms: Dihydropicrasidine AQuassidine B (Dihydropicrasidine A) is a natural alkaloid.
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VIR-2482
0 ImagesCat. No.: HY-P992482VIR-2482 is a monoclonal antibody targeting influenza A hemagglutinin (HA). VIR-2482 is generated by introducing LS mutations (M428L/N434S) into the Fc region of MEDI8852 (HY-P991446). VIR-2482 binds to the conserved HA stem epitope across all 18 influenza A HA subtypes, neutralizes a broad spectrum of H1N1 and H3N2 strains, binds to FcγRIIIa, FcγRIIa and C1q, and induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. VIR-2482 reduces morbidity and mortality caused by seasonal influenza A strains and provides prophylactic protection in mice. VIR-2482 can be used in research related to influenza A disease.
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Lucidafuranocoumarin B
0 ImagesCat. No.: HY-N17083CAS No.: 1422520-77-1Lucidafuranocoumarin B is a natural coumarin.
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Glabratine
0 ImagesCat. No.: HY-N7301CAS No.: 142750-47-8Glabratine is a natural alkaloid.
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(Z)-Pinosylvin monomethyl ether
0 ImagesCat. No.: HY-N16936CAS No.: 143207-76-5(Z)-Pinosylvin monomethyl ether is a natural phenolic compound.
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Physaminimin N
0 ImagesCat. No.: HY-N13761CAS No.: 2131235-87-3Physaminimin N is a natural steroid.
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Mahanimbinol
0 ImagesCat. No.: HY-N9864CAS No.: 77156-13-9Mahanimbinol is a natural alkaloid.
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Bisandrographolide G
0 ImagesCat. No.: HY-N17104CAS No.: 2699680-69-6Bisandrographolide G is a natural diterpene.
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(-)-Mitorubrinic acid
0 ImagesCat. No.: HY-126071CAS No.: 58958-07-9Synonyms: Mitorubrinic acid(-)-Mitorubrinic acid (Mitorubrinic acid) is a polyketide. (-)-Mitorubrinic acid is synthesis by two non-reducing polyketide synthase (PKS) genes (pks12 and pks11) in a sequential manner. (-)-Mitorubrinic is a virulence factor of Penicillium marneffei by improving its intracellular survival in macrophages.
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15(R),19(R)-Hydroxy prostaglandin F2α
0 ImagesCat. No.: HY-158595CAS No.: 1224444-23-8Synonyms: 15(R),19(R)-Hydroxy PGF2α15(R),19(R)-Hydroxy prostaglandin F2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandin F2α. 19(R)-Hydroxy-prostaglandin F2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen.
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Idebenone-SS-20
0 ImagesCat. No.: HY-181124Synonyms: Idebenone-2S-FrFK-NH2Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) is a Idebenone (HY-N0303) derivative conjugated to the mitochondria-targeting peptide SS-20. Idebenone-SS-20 shows neuroprotective and anti-inflammatory effects. Idebenone-SS-20 can preserve mitochondrial membrane potential, enhance ATP production, reduce ROS accumulation, maintain mitochondrial morphology and elevate NAD+/NADH ratio. Idebenone-SS-20 confers robust neuroprotection in a murine model of transient middle cerebral artery occlusion. Idebenone-SS-20 can be used for the research of cerebral.
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L-682,679
0 ImagesCat. No.: HY-120700CAS No.: 126409-24-3L-682,679 is an active compound.
