Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4056)
Related Products (4056)
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(1R,16R)-1-Hydroxycryptotanshinone anhydride
0 ImagesCat. No.: HY-N17039CAS No.: 2132963-89-2(1R,16R)-1-Hydroxycryptotanshinone anhydride is a natural diterpene.
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CP-201
0 ImagesCat. No.: HY-W879307CAS No.: 2460280-41-3CP-201 is a 1,4-Naphthoquinone (HY-W015490) derivative with antiplatelet and antithrombotic activities. CP-201 shows concentration-dependent inhibitory effects on platelet aggregation induced by collagen and thrombin, with IC50 values of 4.1 and 4.6 μM, respectively. CP-201 displays a potent protective effect on pulmonary thrombosis in mice. CP-201 can be used for antithrombotic research.
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Esculeogenin A
0 ImagesCat. No.: HY-N18066CAS No.: 854381-37-6Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is an orally active hepatoprotective, hypolipidemic, and antioxidant agent. Esculeogenin A regulates molecular targets like PPARα, SREBP1, Nrf2, NF-κB, ACAT1/ACAT2 to promote hepatic fatty acid oxidation, suppress de novo lipogenesis, enhance antioxidant defense, and inhibit inflammation. Esculeogenin A improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation, preventing nonalcoholic fatty liver disease in high-fat-diet-fed rats and reducing atherosclerotic lesions in apoE-deficient mice. Esculeogenin A can be used for the research of nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia.
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2,2,7,7-Tetramethyltricyclo[6.2.1.01,6]undec-5-en-4-one
![2,2,7,7-Tetramethyltricyclo[6.2.1.01,6]undec-5-en-4-one](https://file.medchemexpress.com/product_pic/hy-n18250.gif "Click to View 2,2,7,7-Tetramethyltricyclo[6.2.1.01,6]undec-5-en-4-one Product Detail")
0 ImagesCat. No.: HY-N18250CAS No.: 23747-14-02,2,7,7-Tetramethyltricycloundec-5-en-4-one is a phytochemical that can be found in the acetone extract of Laurus nobilis L. leaves grown in Saudi Arabia.
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Batatasin III-3-O-glucoside
0 ImagesCat. No.: HY-N21523CAS No.: 189302-75-8Batatasin III-3-O-glucoside is a bibenzyl glycoside that exists in the tubers of Pleione yunnanensis.
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Desethylene Ciprofloxacin hydrochloride
0 ImagesDesethylene Ciprofloxacin hydrochloride is a major metabolite and degradation product of Ciprofloxacin (HY-B0356). Desethylene Ciprofloxacin hydrochloride inhibits topoisomerase (Topoisomerase) IIα and IIβ-mediated DNA relaxation.
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Lamivudine impurity 9
0 ImagesCat. No.: HY-W587905CAS No.: 145986-11-4Lamivudine impurity 9 is an L-oxathiolanyl nucleoside. Lamivudine impurity 9 exhibits anti-HIV-1 activity with EC50 > 100 μM in human peripheral blood mononuclear cells, and it shows no cytotoxicity even at concentrations up to 100 μM in human peripheral blood mononuclear cells and Vero cells.
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epi-Inositol (Standard)
0 ImagesCat. No.: HY-W016509RCAS No.: 488-58-4epi-Inositol (Standard) is the analytical standard of epi-Inositol (HY-W016509). This product is intended for research and analytical applications. epi-Inositol, a inositol analog, is an antidepressant agent. epi-Inositol shows regulatory effects on expression of the most highly regulated gene in the inositol biosynthetic pathway. epi-Inositol shows antiepileptic effect.
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22-Hydroxycyclolaudenol
0 ImagesCat. No.: HY-N13767CAS No.: 2077090-18-522-Hydroxycyclolaudenol is a natural triterpene.
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7,2',4'-Trihydroxyflavanone
0 ImagesCat. No.: HY-N17197CAS No.: 128837-33-27,2',4'-Trihydroxyflavanone is a natural flavonoid.
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ETB067
0 ImagesCat. No.: HY-113613CAS No.: 1000995-79-8ETB067 is an active compound.
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14-Deoxypoststerone
0 ImagesCat. No.: HY-164357CAS No.: 1360460-98-514-Deoxypoststerone is a steroid compound, a derivative of a steroid hormone.
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Stemospironine
0 ImagesCat. No.: HY-N9392ACAS No.: 66267-46-7Stemospironine is an alkaloid that can be extracted from plants of the genus Hyacinth. Stemospironine is a cough suppressant used to control coughing. Stemospironine can be used for research on inflammatory conditions.
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Haenamindole
0 ImagesCat. No.: HY-N16419CAS No.: 1818844-73-3Haenamindole is an alkaloid. Haenamindole is promising for research of bacterial infection and cancers.
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WAY-300570
0 ImagesN-(4-Chlorophenyl)-3-(4-oxo-5-(thiophen-2-ylmethylene)-2-thioxothiazolidin-3-yl)propanamide is an active molecule.
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Thermopterin
0 ImagesCat. No.: HY-125676CAS No.: 135745-46-9Thermopterin is a derivative of the antimicrobial agent Pterin (HY-W037825) isolated from Methanoculleus thermophilus.
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Eucalyptin acetate
0 ImagesCat. No.: HY-N16887CAS No.: 14004-35-4Eucalyptin acetate is a natural flavonoid.
