Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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FNT12
0 ImagesCat. No.: HY-189260FNT12 is a synthetic heterocyclic derivative of 1,2,4-triazolo[1,5-a]pyrimidine that exhibits narrow-spectrum antibacterial activity against Pseudomonas aeruginosa. FNT12 possesses antibiofilm activity and free radical-scavenging antioxidant activity. FNT12 is predicted to bind to the Pseudomonas aeruginosa quorum-sensing protein LasR. FNT12 can be used in research on Pseudomonas aeruginosa infection.
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WAY-658674
0 ImagesWAY-658674 is an active molecule for the study of amyloid diseases and synucleinopathies.
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15(S)-15-Methyl Prostaglandin F2α ethyl amide
0 ImagesCat. No.: HY-18144315(S)-15-Methyl Prostaglandin F2α ethyl amide (15-Methyl Prostaglandin F2α ethyl amide) is a synthetic Prostaglandin F2α (HY-12956) analogue that stimulates uterine contractions. 15(S)-15-Methyl Prostaglandin F2α ethyl amide can be used for the research of second-trimester pregnancy loss.
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Anticancer agent 356
0 ImagesCat. No.: HY-187330Anticancer agent 356 is a phthaloyl derivative with anticancer activity. Molecular docking results of Anticancer agent 356 show that it binds to the EGFR tyrosine kinase domain, KRIT1-Rap1-HEG1 ternary complex and EF-Pyl-GMPPNP complex, thereby stabilizing the complexes and reducing the flexibility of residues at the binding sites. Anticancer agent 356 exhibits cytotoxicity against prostate cancer cells and breast cancer cells. Anticancer agent 356 can be used in the research of prostate cancer and breast cancer.
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9-Deoxygoniopypyrone
0 ImagesCat. No.: HY-N2792CAS No.: 136685-37-59-Deoxygoniopypyrone is a natural phenolic compound.
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Anticancer agent 274
0 ImagesCat. No.: HY-174240Anticancer agent 274 (Compound 1) is a Sorafenib (HY-10201) analog. Anticancer agent 274 can inhibit the growth of tumor cells, with IC50 values of 0.034 μM and 0.042 μM against SaOS-2 and MNNG-HOS cells, respectively. Anticancer agent 274 has relatively low toxicity to normal cells and can be used in the research of tumors such as osteosarcoma.
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Stachartin D
0 ImagesCat. No.: HY-N8906CAS No.: 1978388-57-6Stachartin D is a natural sesquiterpene.
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Nandinine
0 ImagesNandinine is an orally active derivative of Berberine (HY-N0716). Nandinine enhances AMPK activity, inhibits the activation of IKKβ/NF-κB, and regulates the phosphorylation of IRS-1. Nandinine reverses the abnormal production of adipokines, promotes insulin-mediated glucose uptake, and alleviates insulin resistance. Nandinine improves glucose tolerance and increases the insulin sensitivity index in mice. Nandinine can be used in studies related to insulin resistance.
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Isosyringinoside
0 ImagesCat. No.: HY-N17208CAS No.: 152686-85-6Isosyringinoside is a natural phenylacetylene.
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Wedelobatin B
0 ImagesCat. No.: HY-N17122CAS No.: 1589488-35-6Wedelobatin B is a natural diterpene.
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Phanginin E
0 ImagesCat. No.: HY-N21632CAS No.: 1011528-62-3Phanginin E is a cassane-type furanoditerpene found in the seeds of Caesalpinia sappan L. Phanginin E is used in studies on cassane-type diterpenes and cancer cell cytotoxicity.
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Ampelopsin BF
0 ImagesCat. No.: HY-N16934CAS No.: 482304-83-6Ampelopsin BF is a natural phenolic compound.
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Citranaxanthin
0 ImagesCat. No.: HY-W750691CAS No.: 3604-90-8Citranaxanthin is a carotenoid that can be isolated from Sea Hare Dolabella auriculari. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition.
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Isodihydrocadambine
0 ImagesCat. No.: HY-N13752CAS No.: 55624-02-7Isodihydrocadambine is a natural alkaloid.
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(S)-LY-41
0 ImagesCat. No.: HY-165624ACAS No.: 136296-40-7(S)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S)-LY-41 is a potent and selective 5-HT1A receptor agonist. (S)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S)-LY-41 can induce the 5-HT behavioral syndrome. (S)-LY-41can be used for the research of neurological disease, such as depression and anxiety.
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21,23-Dihydro-21-hydroxy-23-oxonomilinic acid methyl ester
0 ImagesCat. No.: HY-N17118CAS No.: 2243600-34-021,23-Dihydro-21-hydroxy-23-oxonomilinic acid methyl ester is a natural triterpene.
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Linoleylanilide
0 ImagesCat. No.: HY-116509CAS No.: 19878-10-5Synonyms: Linoleic acid anilide; LAALinoleylanilide (Linoleic acid anilide) is a Linoleic acid (HY-N0729) derivative. Linoleylanilide slightly inhibits the PMA (HY-18739)-induced expression of CD11b. Linoleylanilide inhibits serum LDH, GOT and GPT activities. Linoleylanilide decreases red cell counts and hemoglobin content.
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Pseudoginsenoside-RT3
0 ImagesCat. No.: HY-N17404CAS No.: 98474-75-0Pseudoginsenoside-RT3 is a natural product that can be found in Panax notoginseng?(Burkill) F. H. Chen ex C. H. Chow.
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Psammaplysene B
0 ImagesCat. No.: HY-125338CAS No.: 865722-85-6Psammaplysene B is an active compound.
