Linoleylanilide
Linoleylanilide (Linoleic acid anilide) is a Linoleic acid (HY-N0729) derivative. Linoleylanilide slightly inhibits the PMA (HY-18739)-induced expression of CD11b. Linoleylanilide inhibits serum LDH, GOT and GPT activities. Linoleylanilide decreases red cell counts and hemoglobin content.
For research use only. We do not sell to patients.
- CAS No.: 19878-10-5
- Formula: C24H37NO
- Molecular Weight:355.56
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
GPT/ALT |
GOT/AST |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | CC50 |
97.8 μM
Compound: 1g
|
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 33479624] |
| THP-1 | IC50 |
21 μM
Compound: 1g
|
Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
|
[PMID: 33479624] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 19878-10-5
-
Molecular Weight 355.56
-
Formula C24H37NO
-
SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(NC1=CC=CC=C1)=O
-
Synonyms
Linoleic acid anilide; LAA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Khan MF, et al. Heated linoleic acid anilide: toxicity and relevance to toxic oil syndrome. Toxicology. 1991;68(2):143-55. [Content Brief]
[2]. Heiskanen KM, et al. Effect of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of adhesion molecules on human neutrophils. Arch Toxicol. 1997;71(10):627-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Linoleylanilide Related Classifications
HY-116509 Related Classifications
Powered by Bioz