Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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CRA-19156
0 ImagesCat. No.: HY-117647CAS No.: 579511-43-6CRA-19156 is an active compound.
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Homovanillyl alcohol 4-O-glucoside
0 ImagesCat. No.: HY-N13733CAS No.: 104380-15-6Homovanillyl alcohol 4-O-glucoside is a natural phenolic compound.
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Isomogroside IVe
0 ImagesCat. No.: HY-N17476CAS No.: 2146088-06-2Isomogroside IVe is a natural product that can be found in Siraitia grosvenorii?(Swingle)?.
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19-nor-1α,25-Dihydroxyvitamin D3
0 ImagesCat. No.: HY-15364CAS No.: 130447-37-919-nor-1α,25-Dihydroxyvitamin D3 is a vitamin D receptor (VDR) agonist with an EC50 of 4.8 nM. 19-nor-1α,25-Dihydroxyvitamin D3 binds to VDR and promotes gene transcription. 19-nor-1α,25-Dihydroxyvitamin D3 can be used in the research of diseases related to the vitamin D signaling pathway.
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Rhodomollein XIII
0 ImagesCat. No.: HY-N21744CAS No.: 54781-72-5Rhodomollein XIII is a grayanane diterpenoid found in Rhododendron molle and is the 6-O-acetyl derivative of Grayanotoxin III.
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Esculentoside S
0 ImagesCat. No.: HY-N18039CAS No.: 156031-83-3Esculentoside S is a bidesmodic triterpene saponin, found in the leaves of Phytolacca acinosa.
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Cichorioside B
0 ImagesCat. No.: HY-N18344CAS No.: 117037-78-2Cichorioside B (Compound 9) is a sesquiterpene lactone glycoside that can be isolated from Lactuca sativa L var. anagustata.
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Kadsudilactone
0 ImagesCat. No.: HY-N21662CAS No.: 137348-14-2Kadsudilactone is a class of naturally derived 3,4-seco-cycloartane-type tetracyclic triterpenoids, featuring a 9,19-cyclo ring system.
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5-cis Carbaprostacyclin
0 ImagesCat. No.: HY-124363CAS No.: 69609-77-45-cis Carbaprostacyclin is a stable analog of PGI2 based on Carbaprostacyclin (HY-112322). Carbacyclin is a PGI2 receptor agonist and vasodilator that activates PPARδ. 5-cis Carbaprostacyclin induces relaxation of pulmonary vascular tone.
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Spiredine
0 ImagesCat. No.: HY-N16826CAS No.: 60062-45-5Spiredine is a natural alkaloid.
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Anabsinthin
0 ImagesAnabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker.
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Norzine dimalate
0 ImagesCat. No.: HY-A0188CAS No.: 52239-63-1Synonyms: Thiethylperazine dimalateNorzine dimalate (Thiethylperazine dimalate), a Phenothiazine (HY-Y0055) derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Norzine dimalate is also a selective ABCC1activator that reduces amyloid-β load in mice. Norzine dimalate has anti-emetic, antipsychotic and antimicrobial effects.
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Salidroside 3-O-glucopyranoside
0 ImagesCat. No.: HY-N18337CAS No.: 1642575-96-9Salidroside 3-O-glucopyranoside is a phenylethanol glycoside found in the aerial parts of Teucrium polium.
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KF 22678
0 ImagesCat. No.: HY-105368CAS No.: 186643-40-3KF 22678 is a thioester derivative of leinamycin. KF 22678 exhibits a broad antitumor spectrum against human carcinoma xenografts, including lung, colon, ovary, and prostate cancers. KF 22678 can be used for the study of cancer.
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Flamprop-methyl
0 ImagesCat. No.: HY-129290CAS No.: 52756-25-9Synonyms: Mataven; WL-29761Flamprop-methyl is an active compound.
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WAY-639299
0 ImagesWAY-639299 is an active molecule for research into amyloid diseases and synucleinopathies.
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Kaempferol 3-rungioside
0 ImagesCat. No.: HY-N16498CAS No.: 28447-29-2
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23α-Hydroxy-olean-12-en-3-one
0 ImagesCat. No.: HY-N17570CAS No.: 135322-63-323α-Hydroxy-olean-12-en-3-one (Compound 15) is a pentacyclic triterpenoid, which is a natural derivative of the oleanane skeleton.
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Anticancer agent 345
0 ImagesCat. No.: HY-184953CAS No.: 3099598-25-8Anticancer agent 345 is a heterobifunctional anticancer compound that exhibits weak antiproliferative activity against both ERα-overexpressing and non-overexpressing T-Rex 293 cells. Anticancer agent 345 can be used in cancer-related research.
