1. Others Anti-infection
  2. Drug Derivative HIV
  3. Lamivudine impurity 9

Lamivudine impurity 9 is an L-oxathiolanyl nucleoside. Lamivudine impurity 9 exhibits anti-HIV-1 activity with EC50 > 100 μM in human peripheral blood mononuclear cells, and it shows no cytotoxicity even at concentrations up to 100 μM in human peripheral blood mononuclear cells and Vero cells.

For research use only. We do not sell to patients.

Lamivudine impurity 9

Lamivudine impurity 9 Chemical Structure

CAS No. : 145986-11-4

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Description

Lamivudine impurity 9 is an L-oxathiolanyl nucleoside. Lamivudine impurity 9 exhibits anti-HIV-1 activity with EC50 > 100 μM in human peripheral blood mononuclear cells, and it shows no cytotoxicity even at concentrations up to 100 μM in human peripheral blood mononuclear cells and Vero cells[1].

IC50 & Target[1]

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
Vero IC50
>100 μM
Compound: 31
Cytotoxicity was determined in the vero cells infected with HIV-I
Cytotoxicity was determined in the vero cells infected with HIV-I
[PMID: 8423591]
In Vitro

Lamivudine impurity 9 (compound 32) shows no anti-HIV-1 activity in human peripheral blood mononuclear cells (EC50 >100 μM) and exhibits no cytotoxicity up to 100 μM in human peripheral blood mononuclear cells and Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.23

Formula

C8H9FN2O4S

CAS No.
SMILES

O=C1N([C@H]2O[C@@H](CO)SC2)C=C(F)C(=O)N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Lamivudine impurity 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lamivudine impurity 9
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HY-W587905
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